{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:58:27Z","timestamp":1787065107922,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Little is known about long\u2010term outcomes and causes of death for individuals with cutaneous T\u2010cell lymphoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used SEER\u201018 registry data to examine outcomes among 9886 adults with mycosis fungoides (MF), S\u00e9zary syndrome (SS), primary cutaneous anaplastic large cell lymphoma (pcALCL), and subcutaneous panniculitis\u2010like T\u2010cell lymphoma (SPTCL) diagnosed from 2000 to 2018. We calculated overall survival (Kaplan\u2013Meier method), standardized mortality ratios (SMRs), absolute excess risk (AER) of death, and cumulative incidence of cause\u2010specific mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Individuals with CTCL were at increased risk of all\u2010cause mortality relative to age\u2010matched controls, with SMR ranging from 1.57 (95% CI: 1.49\u20131.65) in MF to 5.61 (95% CI: 4.65\u20136.7) in SS. This was true even for those who initially presented with early\u2010stage disease. After a median follow\u2010up of 64\u00a0months, the cumulative incidence of lymphoma\u2010related death was 16.5%, compared to 10.5% other causes, 9.6% cardiovascular, 9.1% second primary malignancy, 1.8% infection, and 1.1% unknown cause. People diagnosed with CTCL were at higher risk of mortality due to leukemia and infectious causes than control populations, but secondary causes made overall minor contributions to total mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This population\u2010level analysis revealed that individuals with CTCL were at increased risk of all\u2010cause mortality relative to age\u2010matched controls and that lymphoma remained a significant cause of death even in those presenting with early\u2010stage disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.1099","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:55:22Z","timestamp":1741712122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Overall and Cause\u2010Specific Mortality Among Patients With Cutaneous T\u2010Cell Lymphoma in the United States"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3584-9296","authenticated-orcid":false,"given":"Lauren","family":"Shea","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2606-0533","authenticated-orcid":false,"given":"Mayur","family":"Narkhede","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology University of Alabama at Birmingham  Birmingham 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