{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T09:37:48Z","timestamp":1775554668934,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Follicular lymphoma (FL) has a heterogeneous prognosis. Progression within 24 months of starting front\u2010line therapy (POD24) is prognostic of overall survival (OS). Despite its prognostic value in early lines, the role of POD24 in relapsed\/refractory (R\/R) patients initiating later lines of therapy (LoTs) is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed the SCHOLAR\u20105 real\u2010world cohort to investigate whether POD24 is prognostic in patients with R\/R FL initiating \u22653rd LoT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 128 SCHOLAR\u20105 patients, 34 patients experienced POD24. POD24 patients received their \u22653 LoT after a shorter time compared with non\u2010POD24 patients (median 42.0 months [range: 8.8\u201217.8] vs. 109.9 months [range: 29.6\u2012310.2]). Using a time\u2010dependent multivariate Cox model, POD24 was predictive of shorter OS from initiation of \u22653rd LoT with a hazard ratio (HR) of 2.44 (95% confidence interval [CI]: 1.20\u20124.96). For progression\u2010free survival, using a multivariate repeated\u2010measures Cox model, the effect was similar but not statistically significant (HR: 1.45; 95% CI: 0.94\u20122.11).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that among patients with R\/R FL initiating a \u22653rd LoT, POD24 patients reach these LoTs sooner after diagnosis and POD24 remains prognostic of subsequent OS. This suggests that POD24 status can inform clinical decision making in this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.1104","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T14:09:44Z","timestamp":1738850984000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The prognostic value of POD24 in relapsed\/refractory follicular lymphoma\u2014A SCHOLAR\u20105 analysis"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5400-8030","authenticated-orcid":false,"given":"Eve H.","family":"Limbrick\u2010Oldfield","sequence":"first","affiliation":[{"name":"RainCity Analytics  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Kanters","sequence":"additional","affiliation":[{"name":"RainCity Analytics  Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markqayne D.","family":"Ray","sequence":"additional","affiliation":[{"name":"Kite, A Gilead Company  Santa Monica California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Best","sequence":"additional","affiliation":[{"name":"Kite, A Gilead Company  Santa Monica California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhu","family":"Palivela","sequence":"additional","affiliation":[{"name":"Kite, A Gilead Company  Santa Monica California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Beygi","sequence":"additional","affiliation":[{"name":"Kite, A Gilead Company  Santa Monica California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anik R.","family":"Patel","sequence":"additional","affiliation":[{"name":"Kite, A Gilead Company  Santa Monica California 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