{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:21:41Z","timestamp":1747149701294,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Chronic infection with human T\u2010cell lymphotropic virus type\u20101 (HTLV\u20101) may result in aggressive adult T\u2010cell leukaemia\/lymphoma (ATL) in 4\u20106% carriers. The majority of this risk arises in carriers infected during infancy, and so each infant has \u223c25% lifetime risk. Other risk factors include a family history of ATL. Antenatal HTLV\u20101 screening is not undertaken in the UK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here we describe four cases of ATL diagnosed during pregnancy and describe strategies to minimise HTLV\u20101 transmission to neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results\/conclusion<\/jats:title><jats:p>These cases highlight undiagnosed HTLV\u20101 in pregnancy which allows ongoing mother to child vertical transmission and risk of future ATL. We recommend the UK National Screening Committee incorporate HTLV\u20101 serology into antenatal screening.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.142","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T14:22:56Z","timestamp":1606314176000},"page":"131-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adult T cell leukaemia\/lymphoma (ATL) in pregnancy: A UK case series"],"prefix":"10.1002","volume":"2","author":[{"given":"Leila","family":"Motedayen Aval","sequence":"first","affiliation":[{"name":"Section of Virology, Imperial College  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Boullier","sequence":"additional","affiliation":[{"name":"Department of Paediatrics St George's University Hospitals NHS Foundation Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermione","family":"Lyall","sequence":"additional","affiliation":[{"name":"Department of Paediatric Infectious Diseases Imperial College Healthcare NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham P.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Haematology Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Ayto","sequence":"additional","affiliation":[{"name":"Department of Haematology Portsmouth Hospitals NHS Trust  Hampshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic F.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Oxford Vaccine Group Department of Paediatrics University of Oxford  Oxford UK"},{"name":"NIHR Oxford Biomedical Research Centre  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard S.","family":"Tedder","sequence":"additional","affiliation":[{"name":"Section of Virology, Imperial College  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon B.","family":"Drysdale","sequence":"additional","affiliation":[{"name":"Department of Paediatrics St George's University Hospitals NHS Foundation Trust  London UK"},{"name":"Oxford Vaccine Group Department of Paediatrics University of Oxford  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham P.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Section of Virology, Imperial College  London UK"},{"name":"National Centre for Human Retrovirology Imperial College Healthcare NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8234-5090","authenticated-orcid":false,"given":"Lucy B.","family":"Cook","sequence":"additional","affiliation":[{"name":"Section of Virology, Imperial College  London UK"},{"name":"Centre for Haematology Imperial College Healthcare NHS Trust  London UK"},{"name":"National Centre for Human Retrovirology Imperial College Healthcare NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-257410"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16318"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15234"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001628"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01124"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.87.152"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007736"},{"key":"e_1_2_3_9_1","article-title":"Adult T\u2010cell leukemia\u2010lymphoma during pregnancy","volume":"2013","author":"Amor MM","year":"2013","journal-title":"Case Rep Oncol Med"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12904"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200206203462519"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.1996.tb01077.x"},{"issue":"3","key":"e_1_2_3_13_1","first-page":"445","article-title":"Adult T\u2010cell leukemia\/lymphoma in pregnancy","volume":"72","author":"Ohba T","year":"1988","journal-title":"Obs Gynecol"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042560-199600001-00005"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19991029)83:3<291::AID-IJC1>3.0.CO;2-P"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.2428"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00501"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01413-10"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j3961"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30402-5"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.17479.1"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.142","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:45:55Z","timestamp":1693197955000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,25]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/jha2.142"],"URL":"https:\/\/doi.org\/10.1002\/jha2.142","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"type":"print","value":"2688-6146"},{"type":"electronic","value":"2688-6146"}],"subject":[],"published":{"date-parts":[[2020,11,25]]},"assertion":[{"value":"2020-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}