{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:59:06Z","timestamp":1789153146225,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Introduction: Thrombotic microangiopathies (TMAs) are rare disorders associated with fatal outcomes if left uncared for. However, healthcare problems in developing countries tend to limit medical assistance to patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Methods: We prospectively studied an Argentine cohort of 294 consecutive patients from 2013 to 2016. Patients\u2019 subcategory classification relied on clinical symptoms and presence or absence of trigger events associated with TMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Main suspected disorders were the primary TMAs known as thrombotic thrombocytopenic purpura (TTP) (n\u00a0=\u00a072\/294, 24%) and atypical haemolytic uraemic syndrome (aHUS) (n\u00a0=\u00a094\/294, 32%). In acute phase, demographic parameters for acquired TTP (aTTP) (n\u00a0=\u00a028) and aHUS (n\u00a0=\u00a047) showed that both groups were characterised by a young median age (37 and 25 years, respectively) and female predominance (60% and 86%). Median of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 activity was significantly lower in aTTP than in aHUS group (1.4%\u00a0vs 83%) and was associated with a more severe thrombocytopenia (15 \u00d7 10<jats:sup>9<\/jats:sup> vs 53 \u00d7 10<jats:sup>9<\/jats:sup>\/L). Creatinine (Cr) and urea (Ur) were significantly increased in aHUS compared to aTTP subjects (Cr: 3.7\u00a0vs 0.7\u00a0mg\/dL, Ur: 118\u00a0vs 33\u00a0mg\/dL). Gastrointestinal and neurological symptoms were more frequent in aHUS and aTTP, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The first description of a TMA cohort in Argentina revealed similar clinical presentations to those of other countries.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.154","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T19:01:48Z","timestamp":1611082908000},"page":"149-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Thrombotic microangiopathies: First report of 294 cases from a single institution experience in Argentina"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0431-1004","authenticated-orcid":false,"given":"C\u00e9lia","family":"Dos Santos","sequence":"first","affiliation":[{"name":"Laboratory of Haemostasis and Thrombosis CONICET National Academy of Medicine Institute of Experimental Medicine  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juvenal","family":"Paiva","sequence":"additional","affiliation":[{"name":"Department of Haemostasis and Thrombosis National Academy of Medicine Haematologic Research Institute \u201cMariano R. Castex\u201d  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Lucila","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Haemostasis and Thrombosis National Academy of Medicine Haematologic Research Institute \u201cMariano R. Castex\u201d  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Agazzoni","sequence":"additional","affiliation":[{"name":"Department of Haemostasis and Thrombosis National Academy of Medicine Haematologic Research Institute \u201cMariano R. Castex\u201d  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Catalina","family":"Kempfer","sequence":"additional","affiliation":[{"name":"Laboratory of Haemostasis and Thrombosis CONICET National Academy of Medicine Institute of Experimental Medicine  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Rotondo","sequence":"additional","affiliation":[{"name":"Department of Haemostasis and Thrombosis National Academy of Medicine Haematologic Research Institute \u201cMariano R. Castex\u201d  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Marta","family":"Casinelli","sequence":"additional","affiliation":[{"name":"Department of Haemostasis and Thrombosis National Academy of Medicine Haematologic Research Institute \u201cMariano R. Castex\u201d  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Fabiana","family":"Alberto","sequence":"additional","affiliation":[{"name":"Department of Haemostasis and Thrombosis National Academy of Medicine Haematologic Research Institute \u201cMariano R. Castex\u201d  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anal\u00eda","family":"S\u00e1nchez\u2010Luceros","sequence":"additional","affiliation":[{"name":"Laboratory of Haemostasis and Thrombosis CONICET National Academy of Medicine Institute of Experimental Medicine  Buenos Aires Argentina"},{"name":"Department of Haemostasis and Thrombosis National Academy of Medicine Haematologic Research Institute \u201cMariano R. Castex\u201d  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1312353"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.11.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2015.03.246"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2014.08.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020528"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17026"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13571"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010208"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.2.610"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07276.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0193"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12935"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445127"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2019.54.3.218"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms6040100"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13654"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11470918"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2017.06.004"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24612"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2018.53.2.130"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/ckj\/sfz066","article-title":"Relative incidence of thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome in clinically suspected cases of thrombotic microangiopathy","volume":"13","author":"Schonermarck U","year":"2019","journal-title":"Clin Kidney J"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200307000-00003"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/111.3.418"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018018432"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-492421"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2003.79"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13295"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2018.07.008"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-019-04233-7"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(17)30026-1"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13882"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2018.10.002"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1603100"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12160"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13571"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2019.08.024"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-019-1314-1"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806311"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.154","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.154","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T03:59:12Z","timestamp":1693367952000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,19]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1002\/jha2.154"],"URL":"https:\/\/doi.org\/10.1002\/jha2.154","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,19]]},"assertion":[{"value":"2020-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}