{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:34Z","timestamp":1786977994917,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Treatment for patients\u00a0&gt;\u00a060 years with classical Hodgkin lymphoma (cHL) is problematic; there is no gold standard, and outcome is poor. Using the Swedish Lymphoma Registry, we analysed all Swedish patients diagnosed with cHL between 2000 and 2014 (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a02345; median age 42 years; 691 patients were\u00a0&gt;60 years). The median follow\u2010up time was 6.7 years. Treatment for elderly patients consisted mainly of ABVD or CHOP, and the younger patients were treated with ABVD or BEACOPP (with no survival difference). In multivariable analysis of patients\u00a0&gt;\u00a060 years, ABVD correlated with better survival than CHOP (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.027), and ABVD became more common over time among patients aged 61\u201370 years (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.0206). Coinciding with the implementation of FDG\u2010PET\/CT, the fraction of advanced\u2010stage disease increased in later calendar periods, also in the older patient group. Survival has improved in cHL patients\u00a0&gt;\u00a060 years (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.027), for whom ABVD seems superior to CHOP.\n                  <\/jats:p>","DOI":"10.1002\/jha2.202","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T19:03:53Z","timestamp":1620327833000},"page":"400-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Real\u2010world data on treatment concepts in classical Hodgkin lymphoma in Sweden 2000\u20132014, focusing on patients aged\u00a0&gt;60 years"],"prefix":"10.1002","volume":"2","author":[{"given":"Bj\u00f6rn Engelbrekt","family":"Wahlin","sequence":"first","affiliation":[{"name":"Division of Haematology, Department of Medicine, Huddinge Karolinska Institutet Stockholm Sweden"},{"name":"Haematology unit Karolinska University Hospital Stockholm 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