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Fifteen healthy African American men (18\u201035 years, 5 SCT, 10 control) completed a strenuous exercise protocol. Microparticle\u2010associated prothrombinase and tissue factor activities, as well as soluble VCAM, total white cell and monocyte count increased transiently in all subjects following exercise. In the SCT group, exercise resulted in increased <jats:sc>d<\/jats:sc>\u2010dimer, erythrocyte phosphatidylserine exposure, as well as increased circulating erythrocyte\u2010 and endothelial\u2010derived microparticle numbers. These alterations could contribute to exercise\u2010related complications in people with SCT.<\/jats:p>","DOI":"10.1002\/jha2.23","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T17:04:25Z","timestamp":1590512665000},"page":"251-254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An exploratory study of the effects of strenuous exercise on markers of coagulation activation, circulating microparticles, and inflammation in sickle cell trait"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1089-723X","authenticated-orcid":false,"given":"Sarah","family":"Skinner","sequence":"first","affiliation":[{"name":"Hematology\/Oncology Division and UNC Blood Research Center University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric 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