{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:37:21Z","timestamp":1775147841917,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Paroxysmal nocturnal hemoglobinuria (PNH) is a very rare clonal autoimmune disease manifesting with hemolysis, thrombosis, or bone marrow failure. We present an atypical association of myasthenia gravis, aplastic anemia, and PNH occurring years after thymectomy. While this association might be extremely rare, it may not be coincidental as there is a common pathophysiology between PNH and aplastic anemia, with the latter reported in several thymoma\/thymectomy cases. Eculizumab was introduced with good efficacy and without safety concern in our patient, leading to long\u2010term control of PNH without worsening of myasthenia gravis.<\/jats:p>","DOI":"10.1002\/jha2.244","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T21:17:27Z","timestamp":1632950247000},"page":"834-837","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Myasthenia gravis and paroxysmal nocturnal hemoglobinuria after thymectomy: A rare association"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2176-227X","authenticated-orcid":false,"given":"Jean","family":"Galtier","sequence":"first","affiliation":[{"name":"Hematology Department Haut\u2010Leveque Hospital University Hospital Center of Bordeaux  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Duval","sequence":"additional","affiliation":[{"name":"Neurology Department Pellegrin Hospital University Hospital Center of Bordeaux  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ir\u00e8ne","family":"Machelart","sequence":"additional","affiliation":[{"name":"Internal Medicine and Infectious Diseases Haut\u2010Leveque Hospital University Hospital Center of Bordeaux  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carine","family":"Greib","sequence":"additional","affiliation":[{"name":"Internal Medicine and Infectious Diseases Haut\u2010Leveque Hospital University Hospital Center of Bordeaux  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estibaliz","family":"Lazaro","sequence":"additional","affiliation":[{"name":"Internal Medicine and Infectious Diseases Haut\u2010Leveque Hospital University Hospital Center of Bordeaux  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Luc","family":"Pellegrin","sequence":"additional","affiliation":[{"name":"Internal Medicine and Infectious Diseases Haut\u2010Leveque Hospital University Hospital Center of Bordeaux  Pessac France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Viallard","sequence":"additional","affiliation":[{"name":"Internal Medicine and Infectious Diseases Haut\u2010Leveque Hospital University Hospital Center of Bordeaux  Pessac France"},{"name":"INSERM U1034  Pessac Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regis Peffault","family":"de la Tour","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie Greffe Centre de r\u00e9f\u00e9rence des aplasies m\u00e9dullaires acquises et constitutionnelles H\u00f4pital Saint Louis AP\u2010HP  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"Internal Medicine and Infectious Diseases Haut\u2010Leveque Hospital University Hospital Center of Bordeaux  Pessac France"},{"name":"INSERM U1034  Pessac Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-311381"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1337"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2010.74"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20340"},{"key":"e_1_2_3_6_1","article-title":"Immune dysregulation after cardiothoracic surgery and incidental thymectomy: maintenance of regulatory T cells despite impaired thymopoiesis","volume":"91","author":"Halnon NJ","year":"2011","journal-title":"Clin Dev Immunol"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.09.005"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.226134"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20699"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMO.S8442"},{"key":"e_1_2_3_11_1","first-page":"928","article-title":"Spontaneous remission of aplastic anemia: a retrospective analysis","volume":"86","author":"Lee JH","year":"2001","journal-title":"Haematologica"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011207"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.244","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.244","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T07:20:43Z","timestamp":1693120843000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,29]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1002\/jha2.244"],"URL":"https:\/\/doi.org\/10.1002\/jha2.244","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,29]]},"assertion":[{"value":"2021-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}