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The effects of SCT on the spleen, for example, are not completely understood, though there have been a number of case reports detailing related complications in diverse populations. Our objective was to perform the first comprehensive case report review of splenic infarction in SCT patients to highlight the relevance of this seemingly rare condition. We conducted an extensive literature search reviewing case reports and case series of acute splenic infarctions from 1970 to 2020. This comprehensive search resulted in 54 articles with a total of 85 individuals. The ages ranged from 7 to 65, 12% were female. Individuals were of African\u2010American (26%), European (16%), South Asian (13%), Middle Eastern (7%), Latin American (7%), North or East African (4%), Mediterranean (4%), West African (1%), and unknown (22%) origins. Although splenic infarct in SCT patients has been associated with high altitudes, 39% of cases reporting altitude occurred below 3000 m. Among cases where HbS values were recorded, 88% occurred in individuals with HbS levels higher than 35%, suggesting that high HbS values may be a risk factor for splenic infarction. Our findings indicate that splenic infarct occurs across a wide range of demographic populations and environmental settings. While our understanding of SCT evolves, the findings here suggest that future advances in research and healthcare could benefit more from real\u2010time surveillance and registry initiation for various SCT outcomes such as splenic infarct.<\/jats:p>","DOI":"10.1002\/jha2.248","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T06:56:58Z","timestamp":1626073018000},"page":"585-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Splenic infarction in sickle cell trait: A comprehensive systematic review of case studies"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0035-2351","authenticated-orcid":false,"given":"Jamal M.","family":"Jefferson","sequence":"first","affiliation":[{"name":"National Human Genome Research Institute, Division of Intramural Research, Social and Behavioral Research Branch National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wynton M.","family":"Sims","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, Division of Intramural Research, Social and Behavioral Research Branch National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nkeiruka","family":"Umeh","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, Division of Intramural Research, Social and Behavioral Research Branch National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3691-8502","authenticated-orcid":false,"given":"Yen Ji Julia","family":"Byeon","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, Division of Intramural Research, Social and Behavioral Research Branch National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2376-0443","authenticated-orcid":false,"given":"Khadijah E.","family":"Abdallah","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, Division of Intramural Research, Social and Behavioral Research Branch National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3649-5442","authenticated-orcid":false,"given":"Vence L.","family":"Bonham","sequence":"additional","affiliation":[{"name":"National Human Genome Research Institute, Division of Intramural Research, Social and Behavioral Research Branch National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5562-1283","authenticated-orcid":false,"given":"Rakhi P.","family":"Naik","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine Johns Hopkins University  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2790-411X","authenticated-orcid":false,"given":"Kim","family":"Smith\u2010Whitley","sequence":"additional","affiliation":[{"name":"Division of Hematology and Director of the Comprehensive Sickle Cell Center Children's Hospital of Philadelphia  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.15063"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/430744"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08273-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.03.049"},{"key":"e_1_2_6_6_1","unstructured":"Hematology ASo. 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