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Grade 3\u20104 infections were reduced from 55% to 5% during a similarly long off\u2010phase (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). Treg and exhausted T\u2010cells increased (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). Six patients restarted ibrutinib at early progression and remain drug\u2010sensitive. Our interim analysis shows a durable off\u2010phase in most patients, with reduced infections and cost\u2010saving potential. If toxicity\u2010driven permanent cessation of ibrutinib will be affected will be explored in the extended study.<\/jats:p>","DOI":"10.1002\/jha2.261","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T12:12:50Z","timestamp":1626264770000},"page":"525-529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Temporary cessation of ibrutinib results in reduced grade 3\u20104 infections and durable remissions\u2014Interim analysis of an on\u2010off\u2010repeat Phase 1b\/2 study in patients with chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4473-5450","authenticated-orcid":false,"given":"Jeanette","family":"Lundin","sequence":"first","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institutet  Stockholm Sweden"},{"name":"Lymphoma Unit, Department of Hematology Karolinska University Hospital Solna  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