{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:52:43Z","timestamp":1788281563722,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The genotype and phenotype correlation between coinheritance of heterozygous beta\u2010thalassemia with the alpha\u2010globin triplication is unclear. In this study we have investigated and reviewed alpha triplication frequency in beta\u2010thalassemia carriers, sickle cell trait, and healthy individuals and its effect on hematological and phenotypical changes. In this study, 4005 beta\u2010thalassemia carriers, 455 sickle cell trait, and 2000 healthy individuals were included. Molecular characterization of beta and alpha\u2010thalassemia was performed. The frequencies of alpha\u2010globin triplication in beta\u2010thalassemia carriers, sickle cell trait, and healthy individuals were 67 (1.67%), 4 (0.88%), and 18 (0.9%), respectively. In total, the frequency of alpha\u2010triplications is approximately 89 (1.39%) in Khuzestan province, South of Iran population. We have compared the average hematological parameters of beta\u2010thalassemia carriers, sickle cell trait, and healthy individuals with and without alpha gene triplication.<\/jats:p><jats:p>This mutation did not show any significant effect on the change of blood indices, neither in healthy individuals nor in sickle cell trait and beta\u2010thalassemia carriers. Therefore, there is no need to take more notice of anti 3.7 mutation in beta\u2010thalassemia carriers is opposed with some studies reported that the presence of excess alpha\u2010globin genes in beta\u2010thalassemia carriers can lead to the phenotype of beta\u2010thalassemia intermedia. Therefore, not every individual with triplicated alpha globin coinherited with beta\u2010thalassemia trait will have a significantly lower Hb than normal, and it is highly likely that none of them will need transfusion.<\/jats:p>","DOI":"10.1002\/jha2.262","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T12:42:33Z","timestamp":1626698553000},"page":"366-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Alpha\u2010globin gene triplication and its effect in beta\u2010thalassemia carrier, sickle cell trait, and healthy individual"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-0713","authenticated-orcid":false,"given":"Mohammad","family":"Hamid","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Biotechnology Research Center Pasteur Institute of Iran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijan","family":"keikhaei","sequence":"additional","affiliation":[{"name":"Research Center for Thalassemia and Hemoglobinopathy, Health Institute Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Galehdari","sequence":"additional","affiliation":[{"name":"Department of Genetics, Faculty of Sciences Shahid Chamran University of Ahvaz  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alihossein","family":"Saberi","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Shariati","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, Faculty of Medicine Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"},{"name":"Narges Medical Genetics and PND Laboratory  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marziye","family":"Mohammadi\u2010Anaei","sequence":"additional","affiliation":[{"name":"Narges Medical Genetics and PND Laboratory  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470696705"},{"key":"e_1_2_10_3_1","unstructured":"TaherA VichinskyE MusallamK CappelliniMD ViprakasitV.Guidelines for the management of non transfusion dependent thalassaemia (NTDT). 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