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Rapidly controlling EMD to prevent end\u2010organ damage is a priority. Retrospectively, we reviewed our database for patients with EMD that received treatment with bortezomib, dexamethasone, cisplatin, doxorubicin, cyclophosphamide, etoposide (VDPACE) plus an immune modulator (IMiD) regimen. We identified 21 patients with a median age of 61 years. Ten patients received a VDPACE based regimen as a bridge to autologus stem cell transplant (ASCT). After a median follow\u2010up of 51.4 months, the median overall survival (OS) and progression\u2010free survival were 14.9 months (95% CI: 7.8\u2010NA) and 5.5 months (95% CI: 3.9\u2010NA), respectively. The overall response rate was 76%, with a manageable safety profile. Interestingly, these results were similar regardless of the presence of high\u2010risk cytogenetics. The safety profile was acceptable. In conclusion, a salvage VDPACE\u2010based regimen plus an IMiD remains an effective and safe bridging therapy to future ASCT and immunotherapy in relapsed\/refractory multiple myeloma patients with EMD.<\/jats:p>","DOI":"10.1002\/jha2.275","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T11:53:39Z","timestamp":1631793219000},"page":"757-764","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes of VDPACE with an immunomodulatory agent as a salvage therapy in relapsed\/refractory multiple myeloma with extramedullary disease"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6603-185X","authenticated-orcid":false,"given":"Al\u2010Ola","family":"Abdallah","sequence":"first","affiliation":[{"name":"Division of Hematologic Malignancies &amp; Cellular Therapeutics University of Kansas Medical Center  Westwood Kansas 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