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However, fluorescence in situ hybridization (FISH) studies with the break\u2010apart probe for MYC gene showed a fusion and two separated signals (red and green, respectively) leading to the interpretation of MYC gene translocation and a false diagnosis of a TH\u2010lymphoma, according to the recent WHO classification. Nevertheless, <jats:italic>PVT1<\/jats:italic> deletion plus <jats:italic>MYC<\/jats:italic> gain\/amplification has been described as a cause of the double\u2010hi transcription profile. These data highlight the need for new criteria to identify these highly aggressive lymphomas.<\/jats:p>","DOI":"10.1002\/jha2.310","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T07:39:44Z","timestamp":1636529984000},"page":"171-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Redefining the high\u2010grade B cell lymphoma with double\/triple rearrangements of MYC and BCL2\/BCL6 genes. Learning from a case report"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-1327","authenticated-orcid":false,"given":"Socorro Mar\u00eda","family":"Rodr\u00edguez\u2010Pinilla","sequence":"first","affiliation":[{"name":"Pathology Department Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz (FJD)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo Nieves","family":"Salgado","sequence":"additional","affiliation":[{"name":"Cytogenetic Department Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz (FJD)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Chamizo","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz (FJD)  Madrid 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