{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:06:56Z","timestamp":1789189616529,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 58\u2010year\u2010old male was diagnosed with splenic B\u2010cell lymphoma\/leukemia, unclassifiable (SPLL\u2010U). The lymphoma transformed into diffuse large B\u2010cell lymphoma (DLBCL), and multidrug chemotherapy and autologous stem cell transplantation achieved complete remission. Two years later, the lymphoma relapsed as SPLL\u2010U. Serial whole\u2010exome sequencing indicated that the mutation profiles were similar between the onset and relapsed samples while those in DLBCL were partially distinctive, which was in line with the clinical course. Hierarchical clustering revealed that an IGLL5 mutation was the founder mutation proceeding the development of the diseases and suggested that KRAS and other mutations might contribute to the transformation.<\/jats:p>","DOI":"10.1002\/jha2.315","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T20:42:08Z","timestamp":1634503328000},"page":"854-860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mutation profiles of diffuse large B\u2010cell lymphoma transformation of splenic B\u2010cell lymphoma\/leukemia, unclassifiable on whole\u2010exome sequencing"],"prefix":"10.1002","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6426-6770","authenticated-orcid":false,"given":"Shuhei","family":"Kurosawa","sequence":"first","affiliation":[{"name":"Hematology Division Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Bunkyo City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7436-972X","authenticated-orcid":false,"given":"Takashi","family":"Toya","sequence":"additional","affiliation":[{"name":"Hematology Division Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Bunkyo City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daichi","family":"Sadato","sequence":"additional","affiliation":[{"name":"Clinical Research Support Center Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Bunkyo City Japan"},{"name":"Research Center for Genome &amp; 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