{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T02:05:34Z","timestamp":1781316334029,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T00:00:00Z","timestamp":1637452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We conducted this retrospective study to characterize the change in chronic lymphocytic leukemia (CLL) treatment patterns between 2005 and 2019, to understand the treatment sequencing across the course of the disease, and to investigate how targeted agents and prognostic testing were implemented into the patient care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included adult patients with CLL treated at the Hospital District of Southwest Finland during the study period. Data were collected from the Turku University Hospital data lake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 122 and 60 patients received first\u2010 and second\u2010line treatments for CLL, respectively. The shift from conventional chemoimmunotherapy to targeted treatments in recent years (2014\u20132019) was observed. The median overall survival times were not reached in patients treated with targeted agents compared to conventional standard treatments in first\u2010 and second\u2010line settings and improved toward the end of the study period. Prognostic testing increased during the study follow\u2010up and patients with unmutated immunoglobulin heavy\u2010chain variable showed significantly poorer overall survival and time\u2010to\u2010next\u2010treatment outcomes than patients with mutated immunoglobulin heavy\u2010chain variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This real\u2010world study implicated added value of targeted chemo\u2010free therapies as reported in randomized clinical trials, and highlighted the necessity of prognostic testing in order to improve treatment selection and patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.322","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T02:39:35Z","timestamp":1637548775000},"page":"291-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characterization of real\u2010world treatment practices and outcomes among patients with chronic lymphocytic leukemia treated in a Finnish tertiary center"],"prefix":"10.1002","volume":"3","author":[{"given":"Juha","family":"Ranti","sequence":"first","affiliation":[{"name":"Department of Hematology and Stem Cell Transplantation Unit Division of Medicine Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katariina","family":"Perkonoja","sequence":"additional","affiliation":[{"name":"Auria Clinical Informatics Turku University Hospital, Hospital District of Southwest Finland  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommi","family":"Kauko","sequence":"additional","affiliation":[{"name":"Auria Clinical Informatics Turku University Hospital, Hospital District of Southwest Finland  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Loponen","sequence":"additional","affiliation":[{"name":"MedEngine Oy  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmi I.","family":"Joensuu","sequence":"additional","affiliation":[{"name":"MedEngine Oy  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8646-314X","authenticated-orcid":false,"given":"Tiina M.","family":"J\u00e4rvinen","sequence":"additional","affiliation":[{"name":"Medical Affairs Janssen\u2010Cilag Oy  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,21]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Finnish Cancer Registry.Cancer statistics.https:\/\/syoparekisteri.fi\/tilastot\/tautitilastot\/Last Accessed September 22 2020."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.96"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30422-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-806398"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.12.051"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30051-1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.14"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv303"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PPO.0000000000000417"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30788-5"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25638"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0602-x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2020.1795159"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01460"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30443-5"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00948"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812836"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817073"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.1021"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-017-0007-7"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.09.019"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.200204"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1246727"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.220194"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3623"},{"key":"e_1_2_11_27_1","unstructured":"R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing Vienna Austria.https:\/\/www.R\u2010project.org\/. 2020."},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01580"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00894"},{"key":"e_1_2_11_30_1","unstructured":"Finnish Hematology Association (SHY).Finnish CLL treatment guidelines.https:\/\/www.hematology.fi\/fi\/hoito\u2010ohjeet\/veritaudit\/kll\/hoitoLast Accessed February 4 2021."},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13273"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-651125"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000336"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1022770"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2764"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-667675"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.10.009"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.322","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T15:23:41Z","timestamp":1693236221000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,21]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/jha2.322"],"URL":"https:\/\/doi.org\/10.1002\/jha2.322","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,21]]},"assertion":[{"value":"2021-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}