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As the clinical use has progressed rather rapidly since the first approval in 2017, toxicities beyond cytokine release syndrome and immune effector cell\u2010associated neurological syndrome have surfaced. Cytopenias are common in\u00a0&lt;30 days (\u201cearly\u201d), 30\u201390 days (\u201cshort\u2010term\u201d) as well as\u00a0&gt;90 days (\u201cprolonged\u201d); and have clinical implications to patient care as well as resource utilization. We review the details of etiology, factors associated with cytopenias, and management considerations for patients with cytopenias for each of these time\u2010frames. This would potentially serve as a clinical guide for hematological toxicity or CAR\u2010T\u2010OPENIA, which is commonly encountered with the use of CAR T\u2010cell therapy.<\/jats:p>","DOI":"10.1002\/jha2.350","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T02:39:36Z","timestamp":1637548776000},"page":"32-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["CAR\u2010T\u2010OPENIA: Chimeric antigen receptor T\u2010cell therapy\u2010associated cytopenias"],"prefix":"10.1002","volume":"3","author":[{"given":"Alankrita","family":"Taneja","sequence":"first","affiliation":[{"name":"Department of Medicine Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sidney Kimmel Comprehensive Cancer Center Johns Hopkins 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