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Genomic profiling of AITL, DLBCL, and MDS samples revealed that the tumor cells from all samples shared common mutations in <jats:italic>TET2<\/jats:italic> and <jats:italic>DNMT3A<\/jats:italic>. In addition, the <jats:italic>IDH2<\/jats:italic> mutation was observed in AITL, and <jats:italic>TP53<\/jats:italic> mutation was observed in DLBCL and MDS. These findings illustrate the clonal relationship between AITL and DLBCL in addition to AITL and MDS, with the latter being increasingly reported. The present findings strongly support the theory of multistep and multilineage tumorigenesis from a common founder clone.<\/jats:p>","DOI":"10.1002\/jha2.354","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T08:50:33Z","timestamp":1638521433000},"page":"211-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["T\u2010cell lymphoma, B\u2010cell lymphoma, and myelodysplastic syndrome harboring common mutations: Trilineage tumorigenesis from a common founder clone"],"prefix":"10.1002","volume":"3","author":[{"given":"Kyoko","family":"Yoshihara","sequence":"first","affiliation":[{"name":"Department of Hematology Hyogo College of Medicine Hospital  Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Nannya","sequence":"additional","affiliation":[{"name":"Department of Pathology and Tumor Biology Kyoto University  Kyoto 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