{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:58:56Z","timestamp":1780387136379,"version":"3.54.1"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was undertaken to identify baseline conditions and triggering factors for skeletal\u2010related events (SRE) in multiple myeloma (MM) patients treated with denosumab. During the median follow\u2010up of 17 months, SRE occurred in 6 out of 52 newly diagnosed patients and in 5 out of 23 relapsed\/refractory patients. Bone fractures occurred by falling down due to orthostatic hypotension and\/or muscle weakness in three out of four cases with amyloid light\u2010chain (AL) amyloidosis. A loss of balance and falling down appear to be triggering factors for SRE, especially in frail MM patients with AL amyloidosis, indicating the importance of retaining physical functions to prevent SRE.<\/jats:p>","DOI":"10.1002\/jha2.402","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T03:33:39Z","timestamp":1646105619000},"page":"480-483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The importance of retaining physical functions to prevent skeletal\u2010related events in multiple myeloma patients with bone disease"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3437-5332","authenticated-orcid":false,"given":"Hirokazu","family":"Miki","sequence":"first","affiliation":[{"name":"Division of Transfusion Medicine and Cell Therapy Tokushima University Hospital  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5465-2758","authenticated-orcid":false,"given":"Shingen","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Medical Science Tokushima University Graduate School of Biomedical Sciences  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Oura","sequence":"additional","affiliation":[{"name":"Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryohei","family":"Sumitani","sequence":"additional","affiliation":[{"name":"Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimiko","family":"Sogabe","sequence":"additional","affiliation":[{"name":"Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Maruhashi","sequence":"additional","affiliation":[{"name":"Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1673-9710","authenticated-orcid":false,"given":"Shiro","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Hamano","sequence":"additional","affiliation":[{"name":"Clinical Research Center for Developmental Therapeutics Tokushima University Hospital  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masateru","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tokushima University Hospital  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tokushima University Hospital  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itsuro","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62051-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3211"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30072-X"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002378"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.402","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:54:12Z","timestamp":1692874452000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/jha2.402"],"URL":"https:\/\/doi.org\/10.1002\/jha2.402","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,28]]},"assertion":[{"value":"2021-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}