{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:53:50Z","timestamp":1775019230149,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T00:00:00Z","timestamp":1593820800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pediatric classical Hodgkin's lymphoma (cHL) is characterized by Hodgkin Reed\u2010Sternberg cells located in an inflammatory microenvironment. Blood biomarkers result from active crosstalk between these cells. One promising biomarker in adult cHL patients is \u201cthymus\u2010and\u2010activation\u2010regulated chemokine\u201d (TARC). The objectives of this study were to define normal TARC values in non\u2010cHL children and to investigate and correlate pretherapy TARC as diagnostic marker in pediatric cHL. In this multicenter prospective study, plasma and serum samples were collected of newly diagnosed cHL patients before start of treatment (n\u00a0=\u00a049), and from randomly selected non\u2010cHL patients (n\u00a0=\u00a081). TARC levels were measured by enzyme\u2010linked immunosorbent assay. The non\u2010cHL patients had a median plasma TARC value of 71 pg\/mL (range: 18\u2010762), compared to 14\u00a0619 pg\/mL (range: 380\u201073\u00a0174) in cHL patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). TARC values had a high discriminatory power (AUC\u00a0=\u00a0.999; 95% confidence interval, .998\u20101). A TARC cutoff level of 942 pg\/mL maximized the sum of sensitivity (97.9%) and specificity (100%). TARC plasma levels were associated with age, treatment level, bulky disease, B\u2010symptoms, and erythrocyte sedimentation rate. TARC was found to be a highly specific and sensitive diagnostic marker for pediatric cHL. This noninvasive marker could be of great value as screening test in the work\u2010up for pediatric patients with lymphadenopathy.<\/jats:p>","DOI":"10.1002\/jha2.41","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T09:39:49Z","timestamp":1593855589000},"page":"152-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Plasma thymus and activation\u2010regulated chemokine (TARC) as diagnostic marker in pediatric Hodgkin lymphoma"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4445-8190","authenticated-orcid":false,"given":"Eline A. M.","family":"Zijtregtop","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Erasmus Medical Centre \u2010 Sophia Children's Hospital  Rotterdam The Netherlands"},{"name":"Department of Hemato\u2010oncology Princess M\u00e1xima Centre for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friederike","family":"Meyer\u2010Wentrup","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010oncology Princess M\u00e1xima Centre for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai\u2010Chu","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Erasmus Medical Centre \u2010 Sophia Children's Hospital  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoull","family":"Hoogendijk","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010oncology Princess M\u00e1xima Centre for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Lopez\u2010Yurda","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010oncology Princess M\u00e1xima Centre for Pediatric Oncology  Utrecht The Netherlands"},{"name":"Department of Biometrics Netherlands Cancer Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian M.","family":"Zwaan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Erasmus Medical Centre \u2010 Sophia Children's Hospital  Rotterdam The Netherlands"},{"name":"Department of Hemato\u2010oncology Princess M\u00e1xima Centre for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Auke","family":"Beishuizen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Erasmus Medical Centre \u2010 Sophia Children's Hospital  Rotterdam The Netherlands"},{"name":"Department of Hemato\u2010oncology Princess M\u00e1xima Centre for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61245"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0099"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428190009087027"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.8401"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.6525"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-08-870915"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2693"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.053199"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.23.15036"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.585"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2017.09.018"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06964.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14317"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200107000-00011"},{"issue":"6","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0002-9440(10)65424-7","article-title":"High expression of the CC chemokine TARC in Reed\u2010Sternberg cells. A possible explanation for the characteristic T\u2010cell infiltratein Hodgkin's lymphoma","volume":"154","author":"den Berg A","year":"1999","journal-title":"Am J Pathol."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.1999.1049"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.525724"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880019409141686"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.11.1630"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12431"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.126079"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12830"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.113237"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.5772\/61749"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23361"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-0100"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjha2.41","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.41","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.41","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.41","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:18:04Z","timestamp":1693891084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.41"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/jha2.41"],"URL":"https:\/\/doi.org\/10.1002\/jha2.41","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"2020-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}