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IgM monoclonal gammopathy of undetermined significance (MGUS) was determined as an underlying disease. After bendamustine and rituximab (BR) therapy was found inadequately effective, tirabrutinib, a novel Bruton's tyrosine kinase inhibitor, was initiated, and the PC normalised subsequently. Surveillance of underlying diseases with which effective therapies are available may help manage refractory ITP, and IgM\u2010MGUS is potentially a targetable underlying disease with this newly available drug.<\/jats:p>","DOI":"10.1002\/jha2.423","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T02:13:39Z","timestamp":1647569619000},"page":"513-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Refractory immune thrombocytopenic purpura associated with IgM monoclonal gammopathy of undetermined significance: Successful treatment with tirabrutinib plus conventional therapies"],"prefix":"10.1002","volume":"3","author":[{"given":"Ryosuke","family":"Naka","sequence":"first","affiliation":[{"name":"Department of Hematology Japanese Red Cross Osaka Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1083-7501","authenticated-orcid":false,"given":"Hitomi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Hematology Japanese Red Cross Osaka Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Hematology Japanese Red Cross Osaka Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Hematology Japanese Red Cross Osaka Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Tashima","sequence":"additional","affiliation":[{"name":"Department of Hematology Japanese Red Cross Osaka Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chisato","family":"Mizutani","sequence":"additional","affiliation":[{"name":"Department of Hematology Japanese Red Cross Osaka Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Imada","sequence":"additional","affiliation":[{"name":"Department of Hematology Japanese Red Cross Osaka Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2009.07615.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2008.07086.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100609.1988.tb00853.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096\u20108652(200102)66:2"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2007.06633.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102009\u201006"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201003\u2010603365"},{"key":"e_1_2_4_9_1","doi-asserted-by":"crossref","unstructured":"DimopoulosMA KastritisE.How I treat waldenstr\u00f6m macroglobulinemia.2019.http:\/\/ashpublications.org\/blood\/article\u2010pdf\/134\/23\/2022\/1545293\/bloodbld2019000725c.pdf. 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