{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T16:17:47Z","timestamp":1700497067338},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019) infection causes a variety of extrapulmonary complications in pediatric patients. Multisystem inflammatory syndrome and hemophagocytic lymphohistiocytosis (HLH) are related to hypercytokinemia in COVID\u201019 patients. HLH is a disorder of exaggerated inflammation resulting in a cytokine storm and unrestricted hemophagocytosis. HLH can be primary (familial) or secondary (acquired). Secondary HLH (sHLH) can occur in patients with rheumatologic, oncologic, or infectious diseases. The link between COVID\u201019 and HLH has been reported in pediatric patients. Here we report a case of a pediatric patient who developed refractory sHLH secondary to COVID\u201019 infection and required a hematopoietic cell transplant for the cure.<\/jats:p>","DOI":"10.1002\/jha2.456","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T06:49:13Z","timestamp":1652338153000},"page":"1025-1028","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["COVID\u201019\u2010associated secondary hemophagocytic lymphohistiocytosis requiring hematopoietic cell transplant"],"prefix":"10.1002","volume":"3","author":[{"given":"Jacob R.","family":"Greenmyer","sequence":"first","affiliation":[{"name":"Pediatric and Adolescent Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk D","family":"Wyatt","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Sanford Health  Fargo North Dakota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Milanovich","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Sanford Health  Fargo North Dakota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mira A.","family":"Kohorst","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa","family":"Ferdjallah","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12245-021-00373-6"},{"key":"e_1_2_7_3_1","article-title":"Immune response to SARS\u2010CoV\u20102 in children: a review of current knowledge","author":"Fillippatos F","year":"2021","journal-title":"Pediatr Investig"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1054-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI140970"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000936"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17669"},{"key":"e_1_2_7_8_1","unstructured":"CDC.Information for healthcare providers about multisystem inflammatory syndrome in children (MIS\u2010C).https:\/\/www.cdc.gov\/mis\/mis\u2010c\/hcp\/index.htmlAccessed February 26 2022."},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2021.08.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2021-322290"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11331"},{"issue":"8","key":"e_1_2_7_12_1","first-page":"997","article-title":"Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis associated with malignancies","volume":"100","author":"Lehmberg K","year":"2015","journal-title":"Haematologica"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14591"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38690"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199705)28:5<342::AID-MPO3>3.0.CO;2-H"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2021.1901576"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.456","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.456","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T03:07:50Z","timestamp":1692587270000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,11]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/jha2.456"],"URL":"https:\/\/doi.org\/10.1002\/jha2.456","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,11]]},"assertion":[{"value":"2022-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}