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Here, we have used a customized NanoString platform to analyze a series of 197 homogeneously treated DLBCL cases. The platform includes the most relevant genes or signatures known to be useful for predicting response to R\u2010CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) in DLBCL cases. We generated a risk score that combines the International Prognostic Index with cell of origin and double expression of <jats:italic>MYC\/BCL2<\/jats:italic>, and stratified the series into three groups, yielding hazard ratios from 0.15 to 5.49 for overall survival, and from 0.17 to 5.04 for progression\u2010free survival. Group differences were highly significant (<jats:italic>p<\/jats:italic>\u00a0&lt; 0.0001), and the scoring system was applicable to younger patients (&lt;60 years of age) and patients with advanced or localized stages of the disease. Results were validated in an independent dataset from 166 DLBCL patients treated in two distinct clinical trials. This risk score combines clinical and biological data in a model that can be used to integrate biological variables into the prognostic models for DLBCL cases.<\/jats:p>","DOI":"10.1002\/jha2.457","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T08:44:06Z","timestamp":1651567446000},"page":"722-733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An integrated prognostic model for diffuse large B\u2010cell lymphoma treated with immunochemotherapy"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8543-6767","authenticated-orcid":false,"given":"Marta","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Pathology Department IIS Hospital Universitario Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"},{"name":"Center for Biomedical Network Research on Cancer (CIBERONC) ISCIII  Madrid 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