{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:22:23Z","timestamp":1747149743471,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Castleman disease (CD) is a rare lymphoproliferative disorder with multiple subtypes. Thrombocytopenia, anasarca, fever, reticulin fibrosis or renal insufficiency, and organomegaly (TAFRO) syndrome can occur in the context of CD. The study evaluated worldwide public awareness of CD and TAFRO syndrome using Google Trends data between 2015 and 2021. Our results showed that global public interest steadily grew until late 2019, at a small but significant rate of 1.1% per month from the 1st to 57th month (1\/2015\u20139\/2019). The increase coincided with a peak in the United States and Japan, but the search volume decreased at a rate of 1.3% per month after that time. No clear trend changes were noted throughout the study period with the search term \u201cTAFRO.\u201d However, the search volume significantly increased during the time period at a rate of 4.8% (confidence interval [CI]: 2.8, 6.8) and 4.7% (CI: 2.7, 6.8) per month in Japan and worldwide, respectively. There was an insufficient search volume for \u201cTAFRO\u201d in the United States to perform the analysis. Most searches on \u201cTAFRO\u201d stemmed from Japan, suggesting considerable geographical disparity in the awareness of TAFRO syndrome. Further efforts are crucial to raise the awareness of CD and TAFRO syndrome among physicians and the general public, primarily in non\u2010USA and Japanese countries.<\/jats:p>","DOI":"10.1002\/jha2.459","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T03:59:40Z","timestamp":1651204780000},"page":"748-753","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Global public awareness of Castleman disease and TAFRO syndrome between 2015 and 2021: A Google Trends analysis"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-7501","authenticated-orcid":false,"given":"Yoshito","family":"Nishimura","sequence":"first","affiliation":[{"name":"Department of Medicine John A. Burns School of Medicine University of Hawai'i  Honolulu Hawaii USA"},{"name":"Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori Filiz","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Fajgenbaum","sequence":"additional","affiliation":[{"name":"Center for Cytokine Storm Treatment and Laboratory Division of Translational Medicine and Human Genetics Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frits","family":"van Rhee","sequence":"additional","affiliation":[{"name":"Myeloma Center University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuharu","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Pathophysiology Okayama University Graduate School of Health Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000931"},{"key":"e_1_2_10_3_1","unstructured":"Castleman Disease Collaborative Network. Castleman Disease Collaborative Network.2021;https:\/\/cdcn.org\/. Accessed 30 Dec 2021."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-746933"},{"issue":"5","key":"e_1_2_10_5_1","first-page":"320","article-title":"Thrombocytopenia with mild bone marrow fibrosis accompanied by fever, pleural effusion, ascites and hepatosplenomegaly","volume":"51","author":"Takai K","year":"2010","journal-title":"Rinsho Ketsueki"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26292"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-016-1979-1"},{"key":"e_1_2_10_8_1","unstructured":"Castleman disease research group. Castleman disease TAFRO and related disease research group.2018. Available from:https:\/\/castleman.jp\/en\/. Accessed 30 Dec 2021."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109583"},{"key":"e_1_2_10_10_1","unstructured":"Google LLC. Google Trends.2021. Available from:https:\/\/trends.google.com\/trends\/. Accessed 30 Dec 2021."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.08.018"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2196\/22910"},{"key":"e_1_2_10_13_1","unstructured":"National Cancer Institute. Joinpoint Trend Analysis Software.2021.https:\/\/surveillance.cancer.gov\/joinpoint\/. Accessed 13 May 2021."},{"key":"e_1_2_10_14_1","unstructured":"ThomasK. His doctors were stumped. Then he took over.2017;https:\/\/www.nytimes.com\/2017\/02\/04\/business\/his\u2010doctors\u2010were\u2010stumped\u2010then\u2010he\u2010took\u2010over.html. Accessed 7 Feb 2022."},{"volume-title":"Chasing my cure: a doctor's race to turn hope into action; a memoir","year":"2019","author":"Farjenbaum D","key":"e_1_2_10_15_1"},{"key":"e_1_2_10_16_1","unstructured":"MasiulieneL LooneyJ AertgeertsH deGreefM. The key features of successful awareness raising campaigns.2013.http:\/\/www.eli\u2010net.eu\/fileadmin\/ELINET\/Redaktion\/user_upload\/The_key_features_of_successful_awareness_raising__campaigns_10\u201015_LM_ELINET.pdf. Accessed 20 July 2021."},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-019-02780-1"},{"key":"e_1_2_10_18_1","unstructured":"Statista. Google: search engine market share in selected countries 2021.2021.https:\/\/www.statista.com\/statistics\/220534\/googles\u2010share\u2010of\u2010search\u2010market\u2010in\u2010selected\u2010countries\/. Accessed 20 July 2021."}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.459","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.459","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T03:06:56Z","timestamp":1692587216000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,28]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/jha2.459"],"URL":"https:\/\/doi.org\/10.1002\/jha2.459","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"type":"print","value":"2688-6146"},{"type":"electronic","value":"2688-6146"}],"subject":[],"published":{"date-parts":[[2022,4,28]]},"assertion":[{"value":"2022-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}