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In the setting of nephrotic\u2010range proteinuria and electrolyte wasting without significant albuminuria or glucosuria, a diagnosis of lysozymuria was made. Lysozymuria is a rare paraneoplastic complication of AML and chronic myelomonocytic leukemia characterized by lysozyme. This represents the first case of lysozymuria presenting primarily with refractory electrolyte derangements rather than severe AKI. Lysozymuria portends a poor clinical prognosis even with aggressive management.<\/jats:p>","DOI":"10.1002\/jha2.464","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T05:19:55Z","timestamp":1652764795000},"page":"1018-1020","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Severe electrolyte derangements from lysozymuria in acute myeloid leukemia"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3312-8663","authenticated-orcid":false,"given":"Juliana","family":"P\u00e9rez\u2010Pinz\u00f3n","sequence":"first","affiliation":[{"name":"School of Medicine Universidad de los Andes  Bogot\u00e1 DC Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca L.","family":"Olin","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology\/Oncology University of California San Francisco  San Francisco 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