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Agents used in myelomaare rational choices and have been employed. Daratumumab has been reported intwo case studies with lenalidomide\u2010dexamethasone, one in the upfront and one inthe relapsed setting. We are the first to report here three cases ofdaratumumab\u2010bortezomib\u2010dexamethasone (DVd) use in relapsed POEMS postautologous stem cell transplant with good VEGF and clinical responses. Our casesadd to the literature on efficacy of daratumumab and are the first to report onits safe use with bortezomib in relapsed POEMS. It should be considered as aclinical option, in patients not responding to conventional first linetherapies.<\/jats:p>","DOI":"10.1002\/jha2.492","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T01:29:27Z","timestamp":1654478967000},"page":"1021-1024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Daratumumab\u2013bortezomib\u2013dexamethasone use in relapsed POEMS syndrome"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4993-7828","authenticated-orcid":false,"given":"Jahanzaib","family":"Khwaja","sequence":"first","affiliation":[{"name":"Department of Haematology University College London Hospitals  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Keh","sequence":"additional","affiliation":[{"name":"Centre for Neuromuscular Disease National Hospital for Neurology and Neurosurgery, Queen Square  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duncan","family":"Smyth","sequence":"additional","affiliation":[{"name":"Centre for Neuromuscular Disease National Hospital for Neurology and Neurosurgery, Queen Square  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Peter","family":"Lunn","sequence":"additional","affiliation":[{"name":"Centre for Neuromuscular Disease National Hospital for Neurology and Neurosurgery, Queen Square  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"D'Sa","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Sive","sequence":"additional","affiliation":[{"name":"Department of Haematology University College London Hospitals  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16057"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.27"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","unstructured":"GavriatopoulouM Ntanasis\u2010StathopoulosI FotiouD MigkouM Eleutherakis\u2010PapaiakovouE KanelliasN et\u00a0al.Upfront daratumumab with lenalidomide and dexamethasone for POEMS syndrome. 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