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Ninety\u2010one patients with CML and 76 controls were included and in total 4 (4.4%) secondary malignancies were found in patients and 8 (10.5%) in controls. The risk for secondary malignancies was not significantly elevated for CML patients (<jats:italic>p<\/jats:italic> = 0.141). Two (2.2%) CML patients developed colorectal cancer compared to 4 (5.3%) in the reference group. A higher risk for CML patients for colorectal cancer could not be found (<jats:italic>p<\/jats:italic> = 0.414).<\/jats:p>","DOI":"10.1002\/jha2.502","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T02:31:21Z","timestamp":1654655481000},"page":"949-953","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long\u2010term observation of the frequency of secondary colorectal cancer and other malignancies in tyrosine kinase inhibitor treated chronic myeloid leukemia patients and controls"],"prefix":"10.1002","volume":"3","author":[{"given":"Nina","family":"Winkelmann","sequence":"first","affiliation":[{"name":"Department of Hematology, Oncology, and Cancer Immunology, Campus Charit\u00e9 Mitte Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, and Cancer Immunology, Campus Virchow\u2010Klinikum Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bert","family":"Hildebrandt","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, and Cancer Immunology, Campus Charit\u00e9 Mitte Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Henke","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, and Cancer Immunology, Campus Charit\u00e9 Mitte Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Bullinger","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, and Cancer Immunology, Campus Virchow\u2010Klinikum Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il\u2010Kang","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, and Cancer Immunology, Campus Virchow\u2010Klinikum Charit\u00e9\u2010 Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Stintzing","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, and Cancer Immunology, Campus Charit\u00e9 Mitte Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4532-1097","authenticated-orcid":false,"given":"Philipp","family":"le Coutre","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, and Cancer Immunology, Campus Charit\u00e9 Mitte Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609324"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2009.07.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26679"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403874"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-362889"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13346"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.20"},{"key":"e_1_2_6_9_1","article-title":"An observational study on risk of secondary cancers in chronic myeloid leukemia patients in the TKI era in the United States","volume":"12","author":"Kumar V","year":"2018","journal-title":"PeerJ"},{"key":"e_1_2_6_10_1","unstructured":"Onkopedia Leitlinien. 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