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Within 1 week of starting CB\u2010103, the bone marrow was free of T\u2010ALL blast infiltration (MRD+) and successfully underwent allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT). Sequential samples of ctDNA to monitor the disease after allo\u2010HSCT showed a decrease of circulating Notch1 and PTEN alterations. This is the first T\u2010ALL patient treated with CB\u2010103. The observed clinical response encourages further exploration of CB\u2010103 in ALL.<\/jats:p>","DOI":"10.1002\/jha2.510","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T06:45:26Z","timestamp":1655448326000},"page":"1009-1012","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["CB\u2010103: A novel CSL\u2010NICD inhibitor for the treatment of NOTCH\u2010driven T\u2010cell acute lymphoblastic leukemia: A case report of complete clinical response in a patient with relapsed and refractory T\u2010ALL"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0427-7747","authenticated-orcid":false,"given":"Michael","family":"Medinger","sequence":"first","affiliation":[{"name":"Department of Hematology University Hospital Basel  Basel Switzerland"},{"name":"University Basel  Basel 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