{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:07:16Z","timestamp":1788286036372,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydroxycarbamide (HC) is used as a cytoreductive treatment in myeloproliferative neoplasms (MPN). Observational studies have raised the possibility that HC contributes to the development of secondary malignancies, including skin tumours in MPN patients. In this retrospective observational study, we report a single\u2010centre experience of 324 HC\u2010treated MPN patients with long\u2010term follow\u2010up, compared to 47 MPN patients not on HC. Thirty\u2010three patients (10.2%) (HC) versus one patient (2.1%) (no HC) developed skin tumours during follow\u2010up (Hazard ratios [HR] 5.70, 95% confidence intervals 0.66\u201348.09, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.112). However, male gender, age at MPN diagnosis, type of MPN (polycythaemia rubra vera) and previous history of skin cancer were prognostic variables associated with development of skin cancer.<\/jats:p>","DOI":"10.1002\/jha2.551","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T01:39:05Z","timestamp":1662169145000},"page":"1305-1309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Skin cancer in essential thrombocythaemia and polycythaemia vera patients treated with hydroxycarbamide"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6952-5927","authenticated-orcid":false,"given":"Abhinav","family":"Mathur","sequence":"first","affiliation":[{"name":"Department Haematology Aberdeen Royal Infirmary Foresterhill Health Campus  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joakim","family":"Edman","sequence":"additional","affiliation":[{"name":"School of Medicine Medical Sciences and Nutrition Aberdeen University  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Liang","sequence":"additional","affiliation":[{"name":"National University Health System National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil W.","family":"Scott","sequence":"additional","affiliation":[{"name":"Institute of Applied Health Sciences University of Aberdeen, Polwarth Building, Foresterhill  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry G.","family":"Watson","sequence":"additional","affiliation":[{"name":"Department Haematology Aberdeen Royal Infirmary Foresterhill Health Campus  Aberdeen UK"},{"name":"School of Medicine Medical Sciences and Nutrition Aberdeen University  Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2010.08122.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15648"},{"key":"e_1_2_8_4_1","first-page":"526","article-title":"Hydroxyurea\u2010induced inhibition of deoxyribonucleotide synthesis: studies in intact cells","volume":"27","author":"Young CW","year":"1967","journal-title":"Cancer 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