{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:53:08Z","timestamp":1782604388706,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Due to differences in the protein folding mechanisms, it is exceedingly rare for amyloid light chain (AL) amyloidosis and monoclonal gammopathy of renal significance (MGRS) to coexist. We herein report the first case of concurrent AL amyloidosis and a subclass of MGRS, light chain proximal tubulopathy (LCPT). The 53\u2010year\u2010old female was diagnosed with smoldering myeloma immunoglobulin G <jats:italic>kappa<\/jats:italic> and AL amyloidosis with deposits in fat and gastrointestinal tissue. The kidney biopsy did not show amyloid deposits but electron microscopy revealed the presence of LCPT with crystal formation in proximal tubular epithelial cells. This case illustrates the complex pathophysiology of protein deposition in monoclonal gammopathies.<\/jats:p>","DOI":"10.1002\/jha2.555","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T18:03:00Z","timestamp":1662660180000},"page":"1377-1380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Concurrent light chain amyloidosis and proximal tubulopathy: Insights into different aggregation behavior\u2014A case report"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9996-4277","authenticated-orcid":false,"given":"Simone","family":"Feurstein","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Section of Hematology, Oncology &amp; Rheumatology University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Zoller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Hematology, Oncology &amp; 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