{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:23:25Z","timestamp":1781580205736,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Amyloid light chain (AL) amyloidosis is a rare and chronic bone marrow disorder. Existing claims data can be used to help understand the real\u2010world treatment patterns and outcomes of this patient population. Various population\u2010based administrative databases in Alberta, Canada were queried from 2010 to mid\u20102019 to identify cases of AL amyloidosis. Baseline patient and disease characteristics, sequencing of pharmacologic therapies, overall survival, and healthcare resource utilization were evaluated. A total of 215 individuals with AL amyloidosis were included. Among patients diagnosed between 2012 and 2019, 149 (85.1%) initiated first\u2010line, 67 (38.3%) initiated second\u2010line, 22 (12.6%) initiated third\u2010line, and 11 (6.3%) initiated fourth\u2010line systemic therapy. In the first\u2010line setting, 99\/149 (66.4%) received bortezomib, cyclophosphamide, and dexamethasone (CyBorD) and 21\/149 (14.1%) received another bortezomib\u2010based regimen. Survival from time of diagnosis improved over time, with a median overall survival of 25.8 months (95% CI: 9.8, 57.1) for individuals diagnosed in 2010\u20132011 versus 52.1 months (95% CI: 25.6, NA) for those diagnosed in 2012\u20132019. Despite this improvement, the proportion of individuals diagnosed in 2012\u20132019 who survived beyond five\u2010years remained low (5\u2010year survival: 48.4%; 95% CI: 40.9, 57.2) which highlights an unmet need for more efficacious therapies.<\/jats:p>","DOI":"10.1002\/jha2.562","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T12:00:22Z","timestamp":1662379222000},"page":"1262-1269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Understanding real\u2010world treatment patterns and clinical outcomes in AL amyloidosis patients diagnosed in Canada: A population\u2010based cohort study"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9294-9437","authenticated-orcid":false,"given":"Victor H.","family":"Jimenez\u2010Zepeda","sequence":"first","affiliation":[{"name":"Department of Medical Oncology and Hematology Tom Baker Cancer Centre  Calgary 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