{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:27:07Z","timestamp":1791296827514,"version":"4.1.0"},"reference-count":81,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Cancer survivors show increased risk for non\u2010communicable diseases and chronic low\u2010grade inflammation characterizes the development of such diseases. We investigated inflammatory plasma protein profiles of survivors of childhood acute lymphoblastic leukemia (ALL) in comparison to healthy controls and after an intervention with a home\u2010based exercise program. Survivors of childhood ALL aged 16\u201330 years (<jats:italic>n<\/jats:italic> = 21) with a median age at diagnosis 4.9 (1.6\u201312.9) years and a median time of 15.9 years from diagnosis, and sex\u2010 and age\u2010matched healthy controls (<jats:italic>n<\/jats:italic> = 21) were studied. Stored plasma samples were analyzed with Olink's 92\u2010protein\u2010wide Inflammation panel in 21 ALL long\u2010term survivors at baseline, after a previous 16\u2010week home\u2010based exercise intervention (<jats:italic>n<\/jats:italic> = 17) and in 21 age\u2010 and sex\u2010matched controls at baseline. Protein expression levels were compared between the groups. Inflammatory protein levels did not differ between the survivors and controls at baseline. Significantly reduced levels after the intervention were found in 11 proteins related to either vascular inflammation, insulin resistance, or both: tumor necrosis factor superfamily member 14 (TNFSF14), oncostatin M (OSM), monocyte chemoattractant protein 1 (MCP\u20101), MCP\u20102, fibroblast growth factor 21 (FGF\u201021), chemokine (C\u2010C motif) ligand 4 (CCL4), transforming growth factor alpha (TGF\u2010\u03b1), tumor necrosis factor\u2010related apoptosis\u2010inducing ligand 10 (TRAIL), adenosine deaminase (ADA), chemokine (C\u2010X\u2010C motif) ligand 6 (CXCL6), and latency\u2010associated peptide transforming growth factor beta 1 (LAP TGF\u2010\u03b21). The ALL survivors were not significantly more affected by inflammation than controls at baseline. The survivors\u2019 16\u2010week exercise intervention led to significant reduction in inflammatory protein levels. Physical exercise should be promoted for survivors of childhood cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.588","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T02:23:48Z","timestamp":1664504628000},"page":"1188-1200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inflammatory biomarkers after an exercise intervention in childhood acute lymphoblastic leukemia survivors"],"prefix":"10.1002","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5243-0382","authenticated-orcid":false,"given":"Tuomas","family":"L\u00e4hteenm\u00e4ki Taalas","sequence":"first","affiliation":[{"name":"University of Turku  Turku Finland"},{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2168-3635","authenticated-orcid":false,"given":"Liisa","family":"J\u00e4rvel\u00e4","sequence":"additional","affiliation":[{"name":"University of Turku  Turku Finland"},{"name":"Department of Pediatrics and Adolescent Medicine Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Niinikoski","sequence":"additional","affiliation":[{"name":"University of Turku  Turku Finland"},{"name":"Department of Pediatrics and Adolescent Medicine Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Huurre","sequence":"additional","affiliation":[{"name":"University of Turku  Turku Finland"},{"name":"Department of Pediatrics and Adolescent Medicine Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2767-5828","authenticated-orcid":false,"given":"Arja","family":"Harila\u2010Saari","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.251"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.8018"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12562"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010018\u20101788\u20105"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201021\u20100667"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(17)31610\u20100"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.3205"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010020\u201005582\u2010y"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880018.2021.1894279"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.940577"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01661"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764\u2010010\u20100131\u20100"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2019.0024"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2019.0137"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506293322602"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","unstructured":"MeeskeKA JiL FreyerDR GaynonP RuccioneK ButturiniA et\u00a0al.Comparative toxicity by sex among children treated for acute lymphoblastic leukemia: a report from the children's oncology group: acute toxicities among male and female patients with ALL. Pediatr Blood Cancer.2015;62(12):2140\u20139.https:\/\/doi.org\/10.1002\/pbc.25628","DOI":"10.1002\/pbc.25628"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24049"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24565"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26051"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.169404"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201009094"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu057"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30857"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224172"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201019\u20102503"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010022\u201001038\u20106"},{"key":"e_1_2_11_29_1","first-page":"26","article-title":"Exercise and inflammation\u2010related epigenetic modifications: focus on DNA methylation","volume":"21","author":"Horsburgh S","year":"2015","journal-title":"Exerc Immunol Rev"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100673\u20102"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01080.2011"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(13)62154\u20106"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2018.0123"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2018.09.009"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201007\u20100048"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29134"},{"key":"e_1_2_11_37_1","unstructured":"What is NPX?Olink. Available from:https:\/\/www.olink.com\/question\/what\u2010is\u2010npx\/. Accessed 8 May 2020."},{"key":"e_1_2_11_38_1","volume-title":"R: a language and environment for statistical computing","author":"R Core Team"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.03.011"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201040906\u2010x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30742"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.176123"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010020\u201000755\u20100"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102005\u201009\u2010010629"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125\u2010016\u20104036\u2010y"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008207.2018.1500558"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892\u2010018\u20101110\u20105"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102007\u201012\u2010129080"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.02.022"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2019.05.007"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07\u20101476"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010010\u20101548\u20104"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12113"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735\u20101097(03)00263\u20108"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2013.59"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010017\u20100620\u20109"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.08.031"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz042"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20051062"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.12.065"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.02.002"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102013\u201009\u2010402560"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395\u2010022\u201000913\u2010y"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.24.021605.090737"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02649"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401961"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/hq1201.098945"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.188078"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12565\u2010017\u20100421\u2010y"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018026294"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2010.01147.x"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-387819-9.00014-1"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25223"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12\u2010205658"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.116.309726"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2003.11.003"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8101391"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010065X.1998.tb01571.x"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374145-5.00334-X"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.107.147009"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470514061.ch6"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.588","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T08:48:00Z","timestamp":1696409280000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":81,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/jha2.588"],"URL":"https:\/\/doi.org\/10.1002\/jha2.588","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,29]]},"assertion":[{"value":"2022-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}