{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:41:15Z","timestamp":1791222075279,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum albumin a well\u2010known risk factor predicting outcome in many solid tumors. We explore the role of low serum albumin (\u22643.5\u00a0g\/dL) as an independent risk factor in elderly patients with aggressive B\u2010cell lymphoma. Outcome of 429 patients treated with R\u2010CHOP\u201014 in the RICOVER\u201060 trial and available serum albumin were analyzed in this retrospective study. Of the 429 patients in the RICOVER\u201060 trial, 137 (32%) had low and 292 (68%) had normal serum albumin levels\u00a0(&gt;3.5\u00a0g\/dL). In the low albumin group, patients had significantly higher International Prognostic Index (IPI), bulky disease, extralymphatic involvement, and B\u2010symptoms. Event\u2010free survival (EFS) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), progression\u2010free survival (PFS) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and overall survival (OS) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) were significantly inferior for patients with low compared to those with normal serum albumin. Multivariate analysis adjusted for IPI shows following Hazard ratios (HR) for low serum albumin: EFS (HR\u00a0=\u00a01.5; 95% confidance interval [CI] [1.1; 2.1], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.009), PFS (HR\u00a0=\u00a01.7; 95% CI [1.2; 2.4], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) and OS (HR\u00a0=\u00a01.6; 95% CI [1.1; 2.3], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006). Results were confirmed in 185 patients from the DENSE\u2010R\u2010CHOP\u201014 and SMARTE\u2010R\u2010CHOP\u201014 trials. In conclusion, low serum albumin is an independent risk factor in elderly patients with aggressive B\u2010cell lymphoma treated with R\u2010CHOP.<\/jats:p>","DOI":"10.1002\/jha2.61","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T06:47:21Z","timestamp":1594709241000},"page":"181-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Low serum albumin is an independent risk factor in elderly patients with aggressive B\u2010cell lymphoma: Results from prospective trials of the German High\u2010Grade Non\u2010Hodgkin's Lymphoma Study Group"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1412-3274","authenticated-orcid":false,"given":"Karin","family":"Hohloch","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Kantonsspital Graub\u00fcnden  Chur Switzerland"},{"name":"Department of Hematology and Oncology University 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