{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:54:34Z","timestamp":1771300474157,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Low\u2010grade lymphomas have a 1%\u20133% annual risk of transformation to a high\u2010grade histology, and prognostic factors remain undefined. We set to investigate the role of positron emission tomography (PET) metrics in identification of transformation in a retrospective case\u2010control series of patients matched by histology and follow\u2010up time. We measured PET parameters including maximum standard uptake value (SUV\u2010max) and total lesion glycolysis (TLG), and developed a PET feature and lactate dehydrogenase (LDH)\u2010based model to identify transformation status within discovery and validation cohorts. For our discovery cohort, we identified 53 patients with transformation and 53 controls with a similar distribution of follicular lymphoma (FL). Time to transformation and control follow\u2010up time was similar. We observed a significant incremental increase in SUV\u2010max and TLG between control, pretransformation and post\u2010transformation groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). By multivariable analysis, we identified a significant interaction between SUV\u2010max and TLG such that SUV\u2010max had highest significance for low volume cases (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). We developed a scoring model incorporating SUV\u2010max, TLG, and serum LDH with improved identification of transformation (area under the curve [AUC]\u00a0=\u00a00.91). Our model performed similarly for our validation cohort of 23 patients (AUC\u00a0=\u00a00.90). With external and prospective validation, our scoring model may provide a specific and noninvasive tool for risk stratification for patients with low\u2010grade lymphoma.<\/jats:p>","DOI":"10.1002\/jha2.615","type":"journal-article","created":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T14:26:50Z","timestamp":1669472810000},"page":"90-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Investigating and modeling positron emission tomography factors associated with large cell transformation from low\u2010grade lymphomas"],"prefix":"10.1002","volume":"4","author":[{"given":"Jean\u2010Pierre","family":"Obeid","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Hiniker","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Schroers\u2010Martin","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Oncology, Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Henry","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-5141","authenticated-orcid":false,"given":"Hyunsoo Joshua","family":"No","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Everett J.","family":"Moding","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjana H.","family":"Advani","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Oncology, Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ash A.","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Oncology, Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard T.","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5461-2438","authenticated-orcid":false,"given":"Michael S.","family":"Binkley","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Stanford University School of Medicine  Stanford California 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