{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T12:13:35Z","timestamp":1751458415175},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670100"],"award-info":[{"award-number":["81670100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We performed a retrospective study to analyze the clinical characteristics and outcomes of human immunodeficiency virus\u2013associated Burkitt's lymphoma in Chongqing University Cancer Hospital, southwest China, from March 2012 to February 2022. In the entire cohort, the median age was 36 years (range, 28\u201360 years), and more patients were male (82.4%). The median CD4<jats:sup>+<\/jats:sup> T cell count was 214\/\u03bcl (range, 54\u2013601), of whom 47.1% had a CD4<jats:sup>+<\/jats:sup> T cell count below 200\/\u03bcl. Most patients had elevated lactate dehydrogenase (LDH), elevated \u03b2<jats:sub>2<\/jats:sub>\u2010MG, extranodal involvement and advanced Ann Arbor stage at diagnosis. With a median follow\u2010up of 11.5 months (range, 1.6\u201394.9 months), the overall 1\u2010year progression\u2010free survival and overall survival (OS) rates were 27.6% and 47.6%, respectively. The 1\u2010year OS times in the LDH\u00a0&lt;\u00a03 upper limit of normal and LDH\u00a0\u2265\u00a03 upper limit of normal groups were 62.5% and 31.3%, respectively (<jats:italic>p\u00a0=<\/jats:italic>\u00a00.008). The 1\u2010year OS times in the received &lt;4 cycles and \u22654 cycles groups were 0% and 77.8%, respectively (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a00.001). These results demonstrated that LDH\u00a0&lt;\u00a03 upper limit of normal and received \u22654 cycles of chemotherapy were significantly associated with improved outcomes. However, rituximab administration was not significantly associated with improved outcomes.<\/jats:p>","DOI":"10.1002\/jha2.624","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T04:32:32Z","timestamp":1671165152000},"page":"100-107","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["HIV\u2010associated Burkitt lymphoma in the combination antiretroviral therapy era: Real\u2010world outcomes and prognostication"],"prefix":"10.1002","volume":"4","author":[{"given":"Chaoyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology Oncology Chongqing University Cancer Hospital Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsi","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology Chongqing University Cancer Hospital Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology Chongqing University Cancer Hospital Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingling","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology Chongqing University Cancer Hospital Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology Chongqing University Cancer Hospital Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology Chongqing University Cancer Hospital Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology Chongqing University Cancer Hospital Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.798008"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615896"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17534"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004099"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(20)30118-1"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000428"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(18)30360-6"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.12.3788"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0595"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-09-871418"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001880"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004458"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11628"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283301578"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10365"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1308392"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00303"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-623900"},{"key":"e_1_2_11_20_1","unstructured":"ChamuleauM StennerF ChituD ChituD NovakU MinnemaM et\u00a0al.R\u2010CODOX\u2010M\/R\u2010IVAC versus dose\u2010 adjusted\u2010EPOCH\u2010R in patients with newly diagnosed high\u2010risk Burkitt lymphoma: first results of a multi\u2010center randomized HOVON\/SAKK trial. 2022 EHA Abstract: LB2370."},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq677"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3362"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.624","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jha2.624","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T13:55:26Z","timestamp":1710338126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,15]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/jha2.624"],"URL":"https:\/\/doi.org\/10.1002\/jha2.624","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,15]]},"assertion":[{"value":"2022-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}