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Overall, 45 patients (median 72 years old) were recruited; the majority were male (71%), had CLL (76%) and were on zanubrutinib (78%). Seroconversion rates were 65% and 77% following two and three doses, respectively. CD4<jats:sup>+<\/jats:sup> and CD8<jats:sup>+<\/jats:sup> T\u2010cell response rates increased with third dose. In zanubrutinib\u2010treated patients, 86% developed either a humoral or cellular response. Patients on zanubrutinib developed substantial immune responses following two COVID\u201019 vaccine doses, which further improved following a third dose.<\/jats:p>","DOI":"10.1002\/jha2.639","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T07:38:58Z","timestamp":1674286738000},"page":"216-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prospective comprehensive profiling of immune responses to COVID\u201019 vaccination in patients on zanubrutinib therapy"],"prefix":"10.1002","volume":"4","author":[{"given":"Thi H. 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