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In a retrospective study of 63 SCD patients, a lower hemoglobin concentration and higher white blood cell count were independently associated with an elevated aPL. SCD patients with elevated aPL had increased pregnancy complications (\u22653 miscarriages, preterm delivery, pre\u2010eclampsia) and venous thrombotic events. Our findings suggest that SCD may predispose to the generation of aPL and that aPL itself may contribute to the vasculopathy of SCD. Prospective testing for aPL is warranted in patients with SCD.<\/jats:p>","DOI":"10.1002\/jha2.643","type":"journal-article","created":{"date-parts":[[2023,1,14]],"date-time":"2023-01-14T05:49:06Z","timestamp":1673675346000},"page":"211-215","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictors and clinical complications associated with antiphospholipid antibodies in sickle cell disease"],"prefix":"10.1002","volume":"4","author":[{"given":"Claudia Rodriguez","family":"Rivera","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Nephrology University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Srisuwananukorn","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology and Oncology Mt Sinai Health System  New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizma Jalees","family":"Bajwa","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor R.","family":"Gordeuk","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology and Oncology University of Illinois at Chicago  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Rauch","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Rheumatology Research Institute of the McGill University Health Centre McGill University  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerrold S.","family":"Levine","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Nephrology University of 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