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We prospectively analyzed the efficacy and safety of autologous peripheral blood SCT (auto\u2010PBSCT) for Ph+ALL patients aged between 55 and 70 years who had achieved complete molecular remission. Melphalan, cyclophosphamide, etoposide, and dexamethasone were used for conditioning. A total of 12 courses of maintenance therapy, including dasatinib, were performed. The required number of CD34<jats:sup>+<\/jats:sup> cells was harvested in all five patients. No patient died within 100 days after auto\u2010PBSCT, and no unexpected serious adverse events were observed. Although 1\u2010year event\u2010free survival was 100%, hematological relapse was observed in three patients at a median of 801 days (range, 389\u20131088 days) after auto\u2010PBSCT. Molecular progressive disease was observed in the other two patients, although they maintained their first hematological remission at the last visit. Auto\u2010PBSCT can be safely performed for Ph+ALL with TKIs. A limitation of auto\u2010PBSCT was suggested, despite the increase in the intensity of a single treatment. The development of long\u2010term therapeutic strategies by including new molecular targeted drugs is warranted to maintain long\u2010term molecular remission.<\/jats:p>","DOI":"10.1002\/jha2.677","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T09:16:41Z","timestamp":1679303801000},"page":"358-369","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Autologous peripheral blood stem cell transplantation for Philadelphia chromosome\u2010positive acute lymphoblastic leukemia is safe but poses challenges for long\u2010term maintenance of molecular remission: Results of the Auto\u2010Ph17 study"],"prefix":"10.1002","volume":"4","author":[{"given":"Satoshi","family":"Nishiwaki","sequence":"first","affiliation":[{"name":"Department of Advanced Medicine Nagoya University Hospital  Nagoya 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