{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:05:44Z","timestamp":1782954344852,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with transfusion\u2010dependent beta (\u03b2)\u2010thalassaemia experience a broad range of complications. ULYSSES, an epidemiological, multicentre, retrospective cross\u2010sectional study, aimed to assess the prevalence and severity of treatment and disease complications, capture disease management and identify predictors of complications in patients with transfusion\u2010dependent \u03b2\u2010thalassaemia, treated in routine settings in Greece. Eligible patients were adults diagnosed with \u03b2\u2010thalassaemia \u226512 months before enrolment and having received \u22656 red blood cell (RBC) units (excluding elective surgery) with no transfusion\u2010free period \u226535 days in the 24\u00a0weeks before enrolment. Primary data were collected at a single visit and through chart review. Between Oct 21, 2019, and Jun 15, 2020, 201 eligible patients [median (interquartile range, IQR) age 45.7 (40.2\u201350.5) years; 75.6%\u00a0&gt;\u00a040 years old; 64.2% female] were enrolled, a mean (standard deviation) of 42.9 (7.8) years after diagnosis. Median (IQR) age at diagnosis and RBC transfusion initiation were 0.8 (0.4\u20132.8) and 1.3 (1.0\u20135.0) years, respectively. From diagnosis to enrolment, patients had developed a median of six (range: 1\u201355) complications; 19.6% were grade \u22653. The most represented complications were endocrine\/metabolic\/nutrition disorders (91.5%), surgical\/medical procedures (67.7%) and blood\/lymphatic system disorders (64.7%). Real\u2010world data generated by ULYSSES underscore the substantial complication burden of transfusion\u2010dependent \u03b2\u2010thalassaemia patients, routinely managed in Greece.<\/jats:p>","DOI":"10.1002\/jha2.695","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T10:28:54Z","timestamp":1684837734000},"page":"569-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Real\u2010world complication burden and disease management paradigms in transfusion\u2010related \u03b2\u2010thalassaemia in Greece: Results from ULYSSES, an epidemiological, multicentre, retrospective cross\u2010sectional study"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5178-0655","authenticated-orcid":false,"given":"Antonis","family":"Kattamis","sequence":"first","affiliation":[{"name":"First Department of Pediatrics Thalassemia Unit National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0979-5722","authenticated-orcid":false,"given":"Ersi","family":"Voskaridou","sequence":"additional","affiliation":[{"name":"Expertise Center in Rare Haematological Diseases\u2010Haemoglobinopathies General Hospital of Athens \u201cLaikon\u201d  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Delicou","sequence":"additional","affiliation":[{"name":"Thalassemia and Sickle Cell Unit General Hospital of Athens \u201cHippocrateion\u201d  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Klironomos","sequence":"additional","affiliation":[{"name":"Thalassemia and Sickle Cell Unit General Hospital of Heraklion \u201cVenizelion\u201d  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Lafiatis","sequence":"additional","affiliation":[{"name":"Thalassemia and Sickle Cell Unit General Hospital of Mytilene \u201cVostanio\u201d  Mytilene Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foteini","family":"Petropoulou","sequence":"additional","affiliation":[{"name":"Thalassemia Unit General Hospital of Athens \u201cGeorgios Gennimatas\u201d  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Diamantidis","sequence":"additional","affiliation":[{"name":"Thalassemia and Sickle Cell Disease Unit General Hospital of Larissa \u201cKoutlimbaneio &amp; 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