{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:12Z","timestamp":1753869432531,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rituximab, a CD20 monoclonal antibody, is used in chronic\/refractory immune thrombocytopenia (ITP). Standard dosing is 375\u00a0mg\/m<jats:sup>2<\/jats:sup> weekly for 4 weeks alongside dexamethasone. A lower dose of Rituximab at 100\u00a0mg weekly demonstrates comparable efficacy that is well tolerated. This study evaluates lower\u2010dose Rituximab with dexamethasone in postpubertal pediatric ITP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients treated with 100\u00a0mg weekly Rituximab for 4 weeks alongside dexamethasone at 10\u00a0mg\/m<jats:sup>2<\/jats:sup> on days 1\u20135 and 21\u201325 were assessed for response and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 10 patients treated, six responded completely, one partially and three showed no response. Four responders maintained their response over 2 years. One Rituximab\u2010related infusion reaction and one Dexamethasone\u2010related adverse event were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rituximab 100\u00a0mg weekly may be non\u2010inferior to 375\u00a0mg\/m<jats:sup>2<\/jats:sup> weekly for paediatric patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.70010","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T09:43:35Z","timestamp":1746092615000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safe and Efficacious Use of Low\u2010Dose Rituximab in Postpubertal Paediatric Patients With Immune Thrombocytopenia"],"prefix":"10.1002","volume":"6","author":[{"given":"Jennifer","family":"Darlow","sequence":"first","affiliation":[{"name":"Royal Manchester Children's Hospital  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0808-8779","authenticated-orcid":false,"given":"Gerard","family":"Gurumurthy","sequence":"additional","affiliation":[{"name":"University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Jeffreys","sequence":"additional","affiliation":[{"name":"Royal Manchester Children's Hospital  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianna","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Royal Manchester Children's Hospital  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vismay","family":"Deshani","sequence":"additional","affiliation":[{"name":"Royal Manchester Children's Hospital  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Grainger","sequence":"additional","affiliation":[{"name":"Royal Manchester Children's Hospital  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-162503"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1475"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2021-323064"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-12-015222"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021010968"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15090"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2020.1745168"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00835"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2008.01100.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.103291"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-229815"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9992086"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01486.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036698"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-582346"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T13:22:40Z","timestamp":1750684960000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.70010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/jha2.70010"],"URL":"https:\/\/doi.org\/10.1002\/jha2.70010","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"type":"print","value":"2688-6146"},{"type":"electronic","value":"2688-6146"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70010"}}