{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:55:55Z","timestamp":1762610155183,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Richter's transformation (RT) from chronic lymphocytic leukemia (CLL) to lymphoma carries poor prognosis. This case series examines the efficacy of lisocabtagene maraleucel (liso\u2010cel) in six RT patients, highlighting the impact of concurrent ibrutinib therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six patients were with RT who received liso\u2010cel from were included in this single institution case series. Clinical data related to efficacy, safety, CAR\u2010T expansion kinetics, and measurable residual disease were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The best overall response was 83.3%. The four patients who received ibrutinib concurrent with liso\u2010cel therapy continue to show MRD\u2010negative complete response till date. None experienced severe (grade 3+) cytokine release syndrome while 1 had severe (grade 3+) immune\u2010effector cell\u2010associated neurotoxicity syndrome (ICANS). All patients were noted to have in vivo CAR expansion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This series of real cases suggests liso\u2010cel with concurrent ibrutinib may be a promising treatment for RT, warranting further exploration.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.70011","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T17:09:47Z","timestamp":1741712987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lisocabtagene Maraleucel for Richter's Transformation\u2014A Case Series"],"prefix":"10.1002","volume":"6","author":[{"given":"Courtney J.","family":"Smith","sequence":"first","affiliation":[{"name":"Division of Blood and Marrow Transplantation and Cellular Therapy Stanford University School of Medicine  Stanford California 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