{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:35:45Z","timestamp":1781620545376,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We retrospectively analysed bortezomib\u2013dexamethasone\u2013rituximab (BDR) combination in patients with Waldenstr\u00f6m macroglobulinaemia (WM) in a real world setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 87 patients were included: 49 patients (56%) were treated in frontline, 22 (25%) in second line and 16 (19%) in third or further line settings. A log\u2010rank test was used to compare overall and event\u2010free survival (OS and EFS) whereas a Gray's test was performed to compare cumulative incidence of deaths and relapse (CID and CIR) according to the IPSS\u2010WM groups, MYD88\/CXCR4 mutational status and line of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall response rate was 88% with five patients (6%) achieving complete response, 20 (24%) very good partial response, 38 (45%) partial response and 11 (13%) minor response. The median time to achieve the best overall response was 9 months and the median EFS was 33 months for whole cohort. Patients treated in third line or further relapse settings had significantly lower median EFS compared to those treated in second\u2010 or first\u2010line setting (13 vs. 36\u00a0vs. 47 months, respectively, <jats:italic>p<\/jats:italic> = 0.01) and a higher 7\u2010year CID (50%\u00a0vs. 13%\u00a0vs. 12% respectively, <jats:italic>p<\/jats:italic> = 0.02). Among patients for whom mutational status was available, MYD88<jats:italic><jats:sup>L265P<\/jats:sup><\/jats:italic> mutation or double mutation MYD88\/CXCR4 did not influence OS or EFS. Severe peripheral neurotoxicity affected 7% of patients and 52 (62%) patients relapsed or died as result of WM whereas 21 patients (24%) died of unrelated causes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BDR represents an interesting chemo\u2010free, fixed duration regimen for patients in first or second line, regardless of mutational status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.70019","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T09:43:07Z","timestamp":1742377387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bortezomib, Rituximab and Dexamethasone Regimen (BDR) in Waldenstr\u00f6m Macroglobulinaemia: A Retrospective Real\u2010World Analysis"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3354-332X","authenticated-orcid":false,"given":"Thomas","family":"Hueso","sequence":"first","affiliation":[{"name":"Clinical Hematology Department Avicenne Hospital (AP\u2010HP) Bobigny France"},{"name":"Early Drug Development Department Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9gory","family":"Lazarian","sequence":"additional","affiliation":[{"name":"Biological Hematology Department Avicenne Hospital (AP\u2010HP) Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Chauvet","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Lille University Hospital University of Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Chauchet","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Besan\u00e7on University Hospital Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramy","family":"Rahm\u00e9","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Avicenne Hospital (AP\u2010HP) Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Brechignac","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Avicenne Hospital (AP\u2010HP) Bobigny France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"L\u00e9vy","sequence":"additional","affiliation":[{"name":"Clinical Research Department Avicenne Hospital (APHP) Bobigny France"},{"name":"Sorbonne Paris Nord University Villetaneuse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7653-711X","authenticated-orcid":false,"given":"Salomon","family":"Manier","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Lille University Hospital University of Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7767-755X","authenticated-orcid":false,"given":"Damien","family":"Roos\u2010Weil","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Piti\u00e9\u2010Salp\u00e9tri\u00e8re Hospital (AP\u2010HP) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2240-2065","authenticated-orcid":false,"given":"David","family":"Ghez","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Gustave Roussy Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Gardin","sequence":"additional","affiliation":[{"name":"Clinical Hematology Department Avicenne Hospital (AP\u2010HP) Bobigny France"},{"name":"Sorbonne Paris Nord University Villetaneuse 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