{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:10Z","timestamp":1753869430307,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300382"],"award-info":[{"award-number":["81300382"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>While coronavirus disease 2019 (COVID\u201019)\u2010associated thrombocytopenia is well\u2010documented, its effects on immune thrombocytopenia (ITP) patients remain unclear. This study aimed to investigate the impact of COVID\u201019 infection on platelet (PLT) dynamics in chronic ITP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study analyzed 21 persistent and chronic ITP patients before and after mild COVID\u201019 infection during China's December 2022 reopening, comparing platelet parameter changes with a focus on clinical characteristics of thrombopoietin receptor agonist (TPO\u2010RA) treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TPO\u2010RA treated patients demonstrated transient platelet surges peaking at 1\u00a0week postinfection, returning to baseline within 2\u20133\u00a0weeks, contrasting sharply with thrombocytopenia patterns in non\u2010ITP populations. This suggests synergistic effects between virus\u2010induced inflammatory cytokines and TPO\u2010RA may drive transient megakaryopoiesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings underscore infection\u2010related PLT fluctuations in ITP, necessitating monitoring for thrombotic and bleeding risks and TPO\u2010RA dose optimization during infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>The authors have confirmed clinical trial registration is not needed for this submission<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.70025","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T17:52:46Z","timestamp":1743443566000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of COVID\u201019 on Platelet Counts in Persistent and Chronic Adult ITP Patients: A Real\u2010World Study in China"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1001-5095","authenticated-orcid":false,"given":"Yujiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University  Wuxi Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University  Wuxi Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University  Wuxi Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University  Wuxi Jiangsu 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