{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:28:10Z","timestamp":1777382890626,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chimeric antigen receptor T (CAR\u2010T) cell therapy is effective for relapsed or refractory multiple myeloma (RRMM); however, relapse after the B\u2010cell maturation antigen (BCMA) CAR\u2010T cell therapy is associated with poor outcome. Hence, appropriate biomarkers that can predict the outcome are needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who received idecabtagene vicleucel, a BCMA\u2010targeted CAR\u2010T cell therapy, were divided into two groups according to a cut\u2010off value of 180 days for the progression\u2010free survival (PFS) event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in the short responder group were older at diagnosis, had a shorter time from diagnosis to apheresis, and more frequently had prior bispecific antibody treatment or alkylator\u2010containing chemotherapies, while they received less immunomodulatory drugs\u2010based chemotherapy just prior to apheresis. Apheresis samples collected from the long responder group had significantly higher proportion of CD8\u2010positive na\u00efve or stem cell memory (CCR7<jats:sup>+<\/jats:sup>CD45RO<jats:sup>\u2212<\/jats:sup>) or central memory (CCR7<jats:sup>+<\/jats:sup>CD45RO<jats:sup>+<\/jats:sup>) T cells. When these two T cell subsets were combined into CCR7\u2010positive CD8 T cells, the patients with high levels of CCR7\u2010positive CD8 T cells showed significantly better PFS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the future, our results will help us to select specific patients that are likely to have a more favorable outcome and should contribute to establishing an optimal application strategy for CAR\u2010T cell therapies in RRMM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.70040","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T09:52:12Z","timestamp":1746438732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of CCR7\u2010Positive CD8 T Cells as a Prognostic Factor in B\u2010Cell Maturation Antigen \u2010Targeted Chimeric Antigen Receptor T Cell 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