{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:38:32Z","timestamp":1779881912458,"version":"3.53.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Chromosome 1q copy gains (with\u20101q\u2010gain) is a frequently observed genetic abnormality in multiple myeloma (MM) patients. Recent research has demonstrated that 1q gain is a prognostic factor, linked to poorer clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted at the Princess Margaret Cancer Centre to examine the clinical outcomes of newly diagnosed MM patients\u2019 with\u20101q\u2010gain or without\u20101q\u2010gain abnormality. The study included 275 patients, with 161 (58.5%) with\u20101q\u2010gain abnormality. The median follow\u2010up time for the cohort was 94.3 months (95% CI 30.1\u201338.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients\u2019 with\u20101q\u2010gain when compared to without\u20101q\u2010gain were more likely to have other high\u2010risk cytogenetic abnormalities (34.8%\u00a0vs. 14.0%, <jats:italic>p<\/jats:italic> &lt; 0.001) and more advanced disease according to the International Staging System (ISS III, <jats:italic>p<\/jats:italic> &lt; 0.014). Furthermore, a relatively higher proportion of with\u20101q\u2010gain patients received tandem autologous stem cell transplant (ASCT) as frontline therapy (36.2%\u00a0vs. 8.7%, <jats:italic>p<\/jats:italic> \u2264 0.001).<\/jats:p><jats:p>To assess the impact of 1q copy number, patients with 3 copies of 1q (1q\u2010gain3) were compared to those with \u22654 copies (1q\u2010Amp). No significant differences were observed between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, our study provides insight into the clinical significance of 1q gain abnormality in MM patients at a single center, and highlights its association with adverse prognostic features and treatment outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.70045","type":"journal-article","created":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T07:39:44Z","timestamp":1746949184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Single\u2010Center Study on Frontline Treatment for Multiple Myeloma Patients With 1q Abnormalities"],"prefix":"10.1002","volume":"6","author":[{"given":"Ashish","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Medical Oncology and Hematology University Health Network\u2010Princess Margaret Cancer Centre  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7271-0680","authenticated-orcid":false,"given":"Esther","family":"Masih\u2010Khan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology University Health Network\u2010Princess Margaret Cancer Centre  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University Health Network\u2010Princess Margaret Cancer Centre  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Lajkosz","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University Health Network\u2010Princess Margaret Cancer Centre  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sita","family":"Bhella","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology University Health Network\u2010Princess Margaret Cancer Centre  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-3669","authenticated-orcid":false,"given":"Christine","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology University Health Network\u2010Princess Margaret Cancer Centre  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5621-9261","authenticated-orcid":false,"given":"Anca","family":"Prica","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology University Health Network\u2010Princess Margaret Cancer Centre  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Reece","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Hematology University Health Network\u2010Princess Margaret Cancer Centre  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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