{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:12Z","timestamp":1753869432625,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Myeloid\u2010derived suppressor cells (MDSCs) play a critical role in immunotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the effects of the Wilms' tumor 1 (WT1) peptide\u2010loaded dendritic cell (DC) vaccination on MDSCs in patients with acute leukemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>WT1\u2010DC vaccination reduced MDSCs and enhanced WT1\u2010specific immunity. In complete remission patients, MDSC reduction was accompanied by decreased arginase 1 and indoleamine 2,3\u2010dioxygenase levels and increased interleukin (IL)\u201012 and interferon\u2010\u03b3 levels in plasma. Conversely, patients with disease progression showed increased IL\u201010 and transforming growth factor\u2010\u03b21. Reduced MDSCs were correlated with WT1\u2010specific immune activation and associated with longer survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings indicate that WT1\u2010DC vaccination suppresses MDSCs and improves clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Trial Registration<\/jats:title><jats:p>This study is registered with the University Hospital Medical Information Network (UMIN) in Japan (Registration ID: UMIN000027279).<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.70048","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T19:38:23Z","timestamp":1747251503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Reduction in Myeloid\u2010derived Suppressor Cells by Wilms\u2019 Tumor 1\u2010targeted Dendritic Cell Vaccines on Clinical Outcomes in Acute Leukemia Patients"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-7146","authenticated-orcid":false,"given":"Masahiro","family":"Ogasawara","sequence":"first","affiliation":[{"name":"Department of Hematology Sapporo Hokuyu Hospital  Sapporo Japan"},{"name":"Institute for Artificial Organ Transplantation and Cell Therapy Sapporo Hokuyu Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamiko","family":"Miyashita","sequence":"additional","affiliation":[{"name":"Institute for Artificial Organ Transplantation and Cell Therapy Sapporo Hokuyu Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Yamagishi","sequence":"additional","affiliation":[{"name":"Cell Processing Center Sapporo Hokuyu Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Ota","sequence":"additional","affiliation":[{"name":"Department of Hematology Sapporo Hokuyu Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016867"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023568"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.13828"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12150"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00490-y"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-023-00475-8"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00846-y"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/17588359211064653"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2017.01.007"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0552-x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6852"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13020210"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1299"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.020"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.11.062"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T13:22:46Z","timestamp":1750684966000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.70048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/jha2.70048"],"URL":"https:\/\/doi.org\/10.1002\/jha2.70048","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"type":"print","value":"2688-6146"},{"type":"electronic","value":"2688-6146"}],"subject":[],"published":{"date-parts":[[2025,5,14]]},"assertion":[{"value":"2024-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70048"}}