{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T03:24:00Z","timestamp":1785381840775,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bispecific antibodies are effective for relapsed\/refractory B\u2010cell lymphoma patients even after CAR\u2010T therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Peripheral blood CAR\u2010T kinetics and functional analysis in vivo were carried out pre\u2010 and post\u2010epcoritamab infusion in B\u2010cell lymphoma patients relapsing after CAR\u2010T therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CAR copy numbers spiked at relapse and rose again following epcoritamab administration. Expression levels of CAR\u2010T exhaustion markers did not increase, whereas perforin and granzyme B expression increased after epcoritamab induction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early epcoritamab administration without cytotoxic agents at relapse after CAR\u2010T therapy revives CAR\u2010T cell numbers and cytotoxicity, which may potentially lead to favorable clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.70079","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T14:54:07Z","timestamp":1750172047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Early Epcoritamab Administration Revives CAR\u2010T Cells in Relapsed\/Refractory B\u2010Cell Lymphomas"],"prefix":"10.1002","volume":"6","author":[{"given":"Kensuke","family":"Yanashima","sequence":"first","affiliation":[{"name":"Department of Hematology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Hamano","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Tsukune","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2896-7737","authenticated-orcid":false,"given":"Hajime","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University School of Medicine  Tokyo Japan"},{"name":"Division of Cell Therapy &amp; Blood Transfusion Medicine Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8871-1330","authenticated-orcid":false,"given":"Miki","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Hematology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804980"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015478"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00662-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-00997-w"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01725"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2024013640"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14102516"},{"issue":"3","key":"e_1_2_10_9_1","first-page":"777","article-title":"Eleven Cases of Laryngeal Edema After tisagenlecleucel Infusion: A 3\u2010Year Single Center Retrospective Study of CD19\u2010Directed Chimeric Antigen Receptor T\u2010Cell Therapy for Relapsed and Refractory B\u2010Cell Lymphomas","volume":"110","author":"Hosoya E.","year":"2025","journal-title":"Haematologica"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012634"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.83"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.10.006"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002842"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T13:23:00Z","timestamp":1750684980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.70079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/jha2.70079"],"URL":"https:\/\/doi.org\/10.1002\/jha2.70079","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"value":"2688-6146","type":"print"},{"value":"2688-6146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2025-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70079"}}