{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:50Z","timestamp":1786978070219,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007249","name":"University of Minnesota","doi-asserted-by":"publisher","award":["N01\u2010HC05185"],"award-info":[{"award-number":["N01\u2010HC05185"]}],"id":[{"id":"10.13039\/100007249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008957","name":"London Health Sciences Centre","doi-asserted-by":"publisher","award":["N01\u2010HC05191"],"award-info":[{"award-number":["N01\u2010HC05191"]}],"id":[{"id":"10.13039\/100008957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007154","name":"Wake Forest University","doi-asserted-by":"publisher","award":["N01\u2010C05192"],"award-info":[{"award-number":["N01\u2010C05192"]}],"id":[{"id":"10.13039\/100007154","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n We sought to determine associations of serum ferritin (SF) with live birth numbers and other iron\u2010related variables in women with\n HFE<\/jats:italic>\n p.C282Y (rs1800562) homozygosity.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We studied non\u2010pregnant, non\u2010Hispanic white women in post\u2010screening evaluations to determine associations of SF with age, pregnancy and live birth numbers, dichotomous menopause and therapeutic phlebotomy reports, daily food and supplemental iron intakes, and transferrin saturation (TS).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were 136 women with mean age 51\u00a0\u00b1\u00a013 (SD) years and median SF 238\u00a0\u00b5g\/L (range: 8, 2960). There were 376 pregnancies (median: 3\/woman (1, 8)) and 296 live births (median: 2\/woman (0, 6)). A total of 70 women (51.5%) reported menopause and 31 women (22.8%) reported phlebotomy. Median heme + non\u2010heme food iron intake was 13.4\u00a0mg\/d (3.1, 57.3). Mean TS was 62\u00a0\u00b1\u00a025%. Pearson's coefficient of ln SF versus age was 0.1955 (\n p<\/jats:italic>\n = 0.0226). Median SF of women with and without menopause was 386\u00a0\u00b5g\/L (8, 2960) and 165\u00a0\u00b5g\/L (8, 1894), respectively (\n p<\/jats:italic>\n \u00a0<\u00a00.0002). SF associations with phlebotomy and iron intakes were not significant. Spearman's coefficient of SF versus TS was 0.5079 (\n p<\/jats:italic>\n \u00a0<\u00a00.0001). Four mean ln SF values of 66 women without menopause subgrouped by live birth numbers were similar (one\u2010way ANOVA\n p<\/jats:italic>\n = 0.4460). Multiple regressions on SF using pregnancy numbers revealed positive associations with menopause (\n p<\/jats:italic>\n = 0.0157) and TS (\n p<\/jats:italic>\n \u00a0<\u00a00.0001) and using live birth numbers revealed positive associations with live births (\n p<\/jats:italic>\n = 0.0389), menopause (\n p<\/jats:italic>\n = 0.0305), and TS (\n p<\/jats:italic>\n \u00a0<\u00a00.0001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n SF levels in 136 women with p.C282Y homozygosity are positively associated with age, numbers of live births, menopause reports and TS.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jha2.70092","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T06:42:51Z","timestamp":1751438571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum Ferritin in Women With\n HFE<\/i>\n p.C282Y Homozygosity: Positive Associations With Age, Live Births, Menopause, and Transferrin Saturation"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2876-8276","authenticated-orcid":false,"given":"James C.","family":"Barton","sequence":"first","affiliation":[{"name":"Department of Medicine The University of Alabama at Birmingham Birmingham Alabama USA"},{"name":"Southern Iron Disorders Center Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2646-4466","authenticated-orcid":false,"given":"J. Clayborn","family":"Barton","sequence":"additional","affiliation":[{"name":"Southern Iron Disorders Center Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8586-6887","authenticated-orcid":false,"given":"Ronald T.","family":"Acton","sequence":"additional","affiliation":[{"name":"Southern Iron Disorders Center Birmingham Alabama USA"},{"name":"Department of Microbiology The University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0896-399"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.10.009"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041534"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k5222"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011338"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07273.x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12602-5"},{"key":"e_1_2_12_9_1","first-page":"1","article-title":"Iron and Hepcidin: A Story of Recycling and Balance","volume":"1","author":"Camaschella C.","year":"2013","journal-title":"Hematology, American Society of Hematology Education Program"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-258467"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20150014"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411002"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07447-0"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-10-3564"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073286"},{"key":"e_1_2_12_16_1","first-page":"678","volume-title":"Wintrobe's Clinical Hematology","author":"Barton J. 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