{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:59:50Z","timestamp":1761389990001,"version":"build-2065373602"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,10]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n We previously reported that sodium\u2010glucose co\u2010transporter 2 (SGLT\u20102) was ectopically overexpressed in adult T\u2010cell leukemia (ATL) cells notably in aggressive type but in indolent type, and widely\u2010used anti\u2010diabetic SGLT\u20102 inhibitors (SGLT\u20102i) considerably attenuated proliferation of leukemic cells.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We performed retrospective analyses for 10 years to see whether SGLT\u20102i would prevent aggressive transformation in patients with indolent type ATL accompanied by diabetes. Nucleosome occupancy in the promotor region of the\n SGLT\u20102<\/jats:italic>\n gene was also assessed to explore the possible involvement of epigenetic modification in such an ectopic overexpression.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In patients of indolent ATL with diabetes, the cumulative progression rate in the non\u2010SGLT\u20102i\u2010treated group was 71%, while no patients developed aggressive transformation in the SGLT\u20102i treated group. ATL cells showed an apparent trend to decrease nucleosome occupancy in the promotor region of the\n SGLT\u20102<\/jats:italic>\n gene.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Our data suggest that SGLT\u20102i is advantageous for preventing aggravative transformation in indolent ATL.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n Authors confirmed that clinical trial registration was not requested for the present study and this manuscript.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jha2.70109","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T15:13:01Z","timestamp":1757344381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SGLT\u20102 Inhibitors Are Potent to Suppress Aggressive Transformation From Indolent Type of Adult T\u2010Cell Leukemia\/Lymphoma: Unique Insight Into Therapeutics for Diabetes\u2010Related Hematological Malignancy"],"prefix":"10.1002","volume":"6","author":[{"given":"Kazuho","family":"Morichika","sequence":"first","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine Graduate School of Medicine University of the Ryukyus Ryukyus Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine Graduate School of Medicine University of the Ryukyus Ryukyus Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Laboratory of Immunohematology School of Health Sciences Faculty of Medicine University of the Ryukyus Ryukyus Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Masuzaki","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Diabetes and Metabolism, Hematology and Rheumatology, Second Department of Internal Medicine Graduate School of Medicine University of the Ryukyus Ryukyus Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208979"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28606"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19835"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112864"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3415"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013568"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.2428"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.118.111807"},{"issue":"4","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1742-4690-10-40","article-title":"LKB1 Tumor Suppressor and Salt\u2010Inducible Kinases Negatively Regulate Human T\u2010Cell Leukemia Virus Type 1 Transcription","volume":"10","author":"Tang H. 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V.","year":"2013","journal-title":"Retrovirology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13303"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007725"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14658"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI154754"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-024-02158-z"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13247"},{"issue":"9","key":"e_1_2_11_17_1","first-page":"2719","article-title":"Vascular Endothelial Growth Factor and Cellular Chemotaxis: A Possible Autocrine Pathway in Adult T\u2010Cell Leukemia Cell Invasion","volume":"7","author":"Hayashibara T.","year":"2001","journal-title":"Clinical Cancer Research"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.02.019"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-662593"}],"container-title":["eJHaem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jha2.70109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:53:18Z","timestamp":1761389598000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jha2.70109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,8]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/jha2.70109"],"URL":"https:\/\/doi.org\/10.1002\/jha2.70109","archive":["Portico"],"relation":{},"ISSN":["2688-6146","2688-6146"],"issn-type":[{"type":"print","value":"2688-6146"},{"type":"electronic","value":"2688-6146"}],"subject":[],"published":{"date-parts":[[2025,9,8]]},"assertion":[{"value":"2025-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70109"}}