{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:30:45Z","timestamp":1787668245200,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["19fm0208013h0003"],"award-info":[{"award-number":["19fm0208013h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21ek0510034"],"award-info":[{"award-number":["JP21ek0510034"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,8]]},"abstract":"ABSTRACT<\/jats:title>Introduction<\/jats:title>Clinically significant cytomegalovirus infection (csCMVi) and non\u2010relapse mortality (NRM) remain serious concerns after allogeneic hematopoietic stem cell transplantation (HSCT), but subpopulations with heterogeneous treatment effects (HTEs) is unclear. Although machine learning (ML) algorithms have recently been applied to HSCT, the methodology has not been well elucidated.<\/jats:p><\/jats:sec>Methods<\/jats:title>We developed a ML algorithm which combined weighting procedures and left\u2010truncated and right\u2010censored trees based on classification and regression tree algorithms to fit survival data with time\u2010varying covariates and competing risks comprehensively. The Japanese large\u2010scale registry data were applied to the algorithm to explore subpopulations with HTEs of csCMVi and NRM after HSCT. Its performance was evaluated by comparing their c\u2010indices with those of the conventional Fine\u2010Gray model.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 10,480 patients were divided into training (75%) and test (25%) cohorts; the training cohort was used to develop the ML model. Using the model, patient CMV\u2010seropositivity, patient age, and acute graft\u2010versus\u2010host disease were identified as important predictors of csCMVi. In addition, the patients were successfully classified by the estimated cumulative incidence of csCMVi, which varied from 22.7% at 0.5 year to 82.7%. This model also depicts interpretable survival trees in various settings. Similarly, the patients can be also classified based on the estimated 3\u2010year NRM, which varied from 8.0% to 48.5%. C\u2010indices of the ML and the Fine\u2010Gray model using the test cohort showed comparable performance.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>A reliable, explainable, and interpretable ML model was developed to explore subpopulations with HTEs of csCMVi and NRM after HSCT.<\/jats:p>Trial Registration<\/jats:bold>: The authors have confirmed clinical trial registration is not needed for this submission<\/jats:p><\/jats:sec>","DOI":"10.1002\/jha2.70117","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T14:19:09Z","timestamp":1754749149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Machine Learning Algorithm to Explore Patients With Heterogeneous Treatment Effects of Clinically Significant CMV Infection and Non\u2010Relapse Mortality After 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