{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:08:00Z","timestamp":1773788880466,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Immune thrombocytopenia (ITP) and antiphospholipid syndrome (APS) are distinct autoimmune disorders with clinical intersections. While APS is marked by thrombosis and pregnancy complications, ITP typically presents as isolated low platelet counts with bleeding risk. Thrombocytopenia can also occur in APS, and a subset of ITP patients test positive for antiphospholipid antibodies (aPL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      This study examined aPL in 90 ITP patients and compared them to 132 APS patients. Among the ITP group, 18.3% were aPL\u2010positive, with lupus anticoagulant most common; 12% had anti\u2010phosphatidylserine\/prothrombin (aPS\/PT) antibodies. In the APS cohort, 16% exhibited thrombocytopenia (&lt; 100,000\/\u00b5L), with a mean platelet count of 44,000\/\u00b5L, and 71% of these were positive for aPS\/PT. Platelet levels varied significantly among ITP aPL\u2010negative, ITP aPL\u2010positive and APS\u2010ITP groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). aPL positivity was linked to less severe thrombocytopenia but affected treatment approaches, showing differences in first\u2010line (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.034) and second\u2010line (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.025) therapies. Patients with ITP secondary to APS had a higher mean platelet count compared to aPL\u2010positive ITP patients and aPL\u2010negative ITP patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Screening for aPL and aPS\/PT is vital to identify an ITP subset with milder thrombocytopenia and increased thrombotic risk, and may guide therapeutic decisions such as between thrombopoietin receptor agonists and SYK inhibitor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>The authors have confirmed clinical trial registration is not needed for this submission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70154","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:21:21Z","timestamp":1759587681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti\u2010Phosphatidylserine\/Prothrombin Antibodies Identify a Distinct Form of ITP"],"prefix":"10.1002","volume":"6","author":[{"given":"Sofia","family":"Camerlo","sequence":"first","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin  Turin Italy"},{"name":"Department of Internal Medicine M. and P. Ferrero Hospital  Verduno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Radin","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences, and ASL Citt\u00e0 di Torino University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERKNet, ERN\u2010Reconnet and RITA\u2010ERN Member) with Nephrology and Dialysis Unit and Center of Immuno\u2010Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Bosco Hub Hospital  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Rosati","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Padrini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Montaruli","sequence":"additional","affiliation":[{"name":"Pathology Division AUO Mauriziano  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2921-1763","authenticated-orcid":false,"given":"Isabella","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Barale","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Barinotti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences, and ASL Citt\u00e0 di Torino University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERKNet, ERN\u2010Reconnet and RITA\u2010ERN Member) with Nephrology and Dialysis Unit and Center of Immuno\u2010Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Bosco Hub Hospital  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Cecchi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences, and ASL Citt\u00e0 di Torino University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERKNet, ERN\u2010Reconnet and RITA\u2010ERN Member) with Nephrology and Dialysis Unit and Center of Immuno\u2010Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Bosco Hub Hospital  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Galarza","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Hospital Del Mar Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fulvio","family":"Pomero","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine M. and P. 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