{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T15:20:25Z","timestamp":1773156025474,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012118","name":"Ontario Institute for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012118","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013873","name":"Government of Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009326","name":"Cancer Research Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["eJHaem"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chimeric antigen receptor T\u2010cell (CART) therapy has shown clinical efficacy in relapsed and refractory large B\u2010cell malignancies. There is emerging data on the long\u2010term complications including risk of secondary malignancies. We aimed to describe the incidence and characteristics of secondary malignancies following CART therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a single\u2010center retrospective analysis of a prospectively collected cohort of 87 patients who received CART therapy for relapsed\/refractory B\u2010cell malignancies between January 2020 and August 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven patients (8.0%) developed a secondary malignancy, with a median age of 57 years (40\u201377) and mean time to onset of 16.9 months (3\u201334.5 months). Two patients were diagnosed with MDS and five with AML. Six patients had cytogenetic abnormalities at diagnosis of MDS\/AML. Five patients received hypomethylating agents and two received an allogeneic stem cell transplant as treatment for their myeloid malignancy. Two patients were alive at 12 months after diagnosis of their myeloid malignancy. The 12\u2010month cumulative incidence function (CIF) was 2.3% (95% CI, 0.4%\u20137.3%) and the 24\u2010month CIF was 6.9% (95% CI, 2.4%\u201314.4%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Development of a secondary malignancy is a potential complication following CART therapy. Results of this single\u2010center study should be confirmed with larger multicenter studies.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration<\/jats:bold>\n                      : The authors have confirmed clinical trial registration is not needed for this submission.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jha2.70164","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T15:02:08Z","timestamp":1761663728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Secondary Malignancies Following CAR T\u2010Cell Therapy for B\u2010Cell Malignancies: A Retrospective Analysis"],"prefix":"10.1002","volume":"6","author":[{"given":"Joanne","family":"Britto","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences McMaster University  Hamilton Ontario Canada"},{"name":"Department of Oncology McMaster University  Hamilton Ontario Canada"},{"name":"Hamilton Health Sciences \u2010 Juravinski Hospital and Cancer Centre  Hamilton Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey Y. 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